Skip to search formSkip to main contentSkip to account menu

OPC 18790

Known as: OPC-18790 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

toborinone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Electropharmacologic Effects of a New Phosphodiesterase III Inhibitor, Toborinone (OPC‐18790), Assessed in an In Vivo Canine Model
Summary: Electropharmacologic effects of a new phosphodiesterase (PDE) III inhibitor toborinone (OPC‐18790) were assessed in a… 
1997
1997
Inhibition of cardiac potassium currents by the vesnarinone analog OPC-18790: comparison with quinidine and dofetilide.
OPC-18790 is a vesnarinone analog currently in clinical trials for treatment of heart failure. In vitro studies have shown that… 
Highly Cited
1996
Highly Cited
1996
Acute cardiovascular effects of OPC-18790 in patients with congestive heart failure. Time- and dose-dependence analysis based on pressure-volume relations.
BACKGROUND OPC-18790 is a water-soluble quinolinone derivative that shares the pharmacological properties of vesnarinone and that… 
1996
1996
Mechanism of action of OPC-8490 in human ventricular myocardium.
BACKGROUND The quinolinone compounds OPC-8212 (vesnarinone), OPC-18790, and OPC-8490 are members of a family of unique positive… 
1996
1996
Effects of toborinone (OPC-18790), a new positive inotropic agent, on action potential in guinea pig sinoatrial node: compared with milrinone and E-4031.
The effects of toborinone ([(+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2 (1H)-quinolinone], OPC-18790), milrinone… 
1995
1995
Differential effects of OPC‐18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea‐pig isolated ischaemic heart
1 The effects of OPC‐18790, a novel positive inotropic agent, on cardiac function and myocardial energy metabolism in the guinea… 
1994
1994
Effects of a Novel Cardiotonic Agent (±)-6-[3-(3,4‐Dimethoxybenzylamino)-2‐Hydroxypropoxy]-2(1H)-Quinolinone (OPC‐18790) on Contractile Force, Cyclic AMP Level, and Aequorin Light Transients in Dog…
Summary: We studied the effects of a novel cardiotonic agent OPC-18790 [(±)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2… 
1994
1994
Pharmacokinetics and Pharmacodynamics of Intravenous OPC‐18790 in Humans: A Novel Nonglycosidic Inotropic Agent
OPC‐18790, a nonglycosidic intropic agent, is now under clinical development for treatment of congestive heart failure. Two… 
1993
1993
Effects of OPC-18790, a new positive inotropic agent, on canine ventricular arrhythmias.
OPC-18790 is a positive inotropic and vasodilating agent that increases intracellular cyclic AMP and stimulates Ca currents. We… 
Highly Cited
1992
Highly Cited
1992
Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives.
A series of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinones has been synthesized and evaluated for positive inotropic activity on… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)