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OPC 18790

Known as: OPC-18790 
National Institutes of Health

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1 relation

Broader (1)

toborinone

Papers overview

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2005
2005
Cardiovascular actions of OPC-18790: A novel positive inotropic agent with little chronotropic action
SummaryOPC-18790 [(±)-6-[3-(3,4-dimethoxy-benzylamino)- 2 - hydroxypropoxy] - 2(1H) - quinolinone], a novel positive inotropic… 
2001
2001
Electropharmacologic Effects of a New Phosphodiesterase III Inhibitor, Toborinone (OPC‐18790), Assessed in an In Vivo Canine Model
Summary: Electropharmacologic effects of a new phosphodiesterase (PDE) III inhibitor toborinone (OPC‐18790) were assessed in a… 
1998
1998
Acute effects of toborinone on vascular capacitance and conductance in experimental heart failure.
BACKGROUND Toborinone (OPC-18790), a phosphodiesterase III inhibitor, enhances cardiac contractility and is an arterial dilator… 
1997
1997
Effect of dobutamine and OPC-18790 on diastolic chamber stiffness in patients with idiopathic dilated cardiomyopathy.
We investigated the acute effects of the positive inotropic agents (dobutamine and a novel phosphodiesterase inhibitor OPC-18790… 
1996
1996
Effects of toborinone (OPC-18790), a new positive inotropic agent, on action potential in guinea pig sinoatrial node: compared with milrinone and E-4031.
The effects of toborinone ([(+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2 (1H)-quinolinone], OPC-18790), milrinone… 
1996
1996
Mechanism of action of OPC-8490 in human ventricular myocardium.
BACKGROUND The quinolinone compounds OPC-8212 (vesnarinone), OPC-18790, and OPC-8490 are members of a family of unique positive… 
1995
1995
Differential effects of OPC‐18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea‐pig isolated ischaemic heart
1 The effects of OPC‐18790, a novel positive inotropic agent, on cardiac function and myocardial energy metabolism in the guinea… 
1995
1995
Cardiovascular effects of the combination of OPC-18790 and dopamine in halothane-anesthetized dogs.
OPC-18790, (+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quin olinone, is a novel positive inotropic agent, and… 
1994
1994
Effects of a Novel Cardiotonic Agent (±)-6-[3-(3,4‐Dimethoxybenzylamino)-2‐Hydroxypropoxy]-2(1H)-Quinolinone (OPC‐18790) on Contractile Force, Cyclic AMP Level, and Aequorin Light Transients in Dog…
Summary: We studied the effects of a novel cardiotonic agent OPC-18790 [(±)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2… 
1994
1994
Pharmacokinetics and Pharmacodynamics of Intravenous OPC‐18790 in Humans: A Novel Nonglycosidic Inotropic Agent
OPC‐18790, a nonglycosidic intropic agent, is now under clinical development for treatment of congestive heart failure. Two… 
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