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An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population
The study examines the effects of the antioxidant flavonoid Pycnogenol on a range of cognitive and biochemical measures in healthy elderly individuals. The study used a double-blind,Expand
OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats.
TLDR
It is demonstrated that OPC-41061 is a highly potent human AVP V2-receptor antagonist and produces clear aquaresis after single and multiple dosing, suggesting the usefulness in the treatment of various water retaining states. Expand
Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats.
TLDR
It is suggested that OPC-41061 produces aquaresis leading to increased serum sodium without affecting the RAA-system, and furosemide produced natriuresis, leading to decreased serum sodium level and activation of the R AA-system. Expand
OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist.
TLDR
An orally effective, nonpeptide, vasopressin V1 receptor antagonist, OPC-21268, has been identified and may be therapeutically useful in the treatment of hypertension and congestive heart failure. Expand
Biphasic effects of D3-receptor agonists, 7-OH-DPAT and PD128907, on the D1-receptor agonist-induced hyperactivity in mice.
TLDR
Results suggest that lower doses of 7-OH-DPAT and PD128907 may negatively influence the D1-receptor mediated behaviors via post synaptic D3-receptors, on the other hand, higher doses of these compounds may positively influence these behaviors via D2- or D3. Expand
Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives.
TLDR
The compounds are the most promising agents with desirable biological activities, and now are currently undergoing clinical evaluation. Expand
Evaluation of the histamine H1-antagonist-induced place preference in rats.
TLDR
The results suggest that some H1 antagonists induce rewarding effects, which may be mediated by the activation of dopamine D1 receptors, followed by the inhibition of dopamine uptake, in the limbic forebrain. Expand
On the mechanisms for the selective action of vitamin D analogs.
TLDR
The primary interest is the potential of OCT in treating the secondary hyperparathyroidism of CRF, and the effects of low binding to DBP on the percentage uremic dogs. Expand
Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries?
TLDR
The results suggest that staurosporine is a relatively specific inhibitor of protein kinase C in intact arteries at lower concentrations, while at higher concentrations it may have actions unrelated to its inhibitory effect of protein Kinase C, which include the inhibition of calcium influx into smooth muscle cells through the voltage-dependent Ca++ channel. Expand
7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist.
TLDR
The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Expand
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