tiazofurin

Known as: 2-ribofuranosylthiazole-4-carboxamide, Riboxamide, TCAR 
A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4… (More)
National Institutes of Health

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Topic mentions per year

1983-2017
0102019832017

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Highly Cited
2004
Highly Cited
2004
NAD+ is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADPribosyl groups used in… (More)
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2002
2002
Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT) is an indispensable enzyme in the biosynthesis of… (More)
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1993
1993
Tiazofurin exhibits antitumor activity in murine and human tumor cells. In a recent phase I/II trial in patients with end-stage… (More)
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1989
1989
Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193), a selective inhibitor of the activity of IMP dehydrogenase… (More)
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1988
1988
The inhibitory mechanisms of ribavirin 5'-monophosphate (RMP) and thiazole-4-carboxamide adenine dinucleotide (TAD), the active… (More)
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1988
1988
The synthetic nucleoside analogue, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193) is an inhibitor of the… (More)
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1987
1987
A patient with refractory acute myeloid leukemia was treated with tiazofurin, an agent that causes inhibition of tumor cell… (More)
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1986
1986
This study reports the selective sensitivity to tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC-286193) of human… (More)
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1985
1985
The mechanism of the cellular toxicity of four inosinate dehydrogenase (IMP-DH) inhibitors with different antitumor and antiviral… (More)
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1984
1984
Tiazofurin, a C-nucleoside, was cytotoxic in hepatoma 3924A cells grown in culture with an LC50 = 7.5 microM. In the culture, a… (More)
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