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tiazofurin

Known as: 2-ribofuranosylthiazole-4-carboxamide, Riboxamide, TCAR 
A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

2-beta-D-ribofuranosylthiazole-4-carboxamideNSC 286193Tiazole

Broader (3)

Antimetabolites, AntineoplasticAntineoplastic AgentsRibavirin
IMPDH1, humanNCIt Antineoplastic Agent TerminologyPurine Synthesis Inhibitionanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1996
Review
1996
Inositol lipid cycle and autonomous nuclear signalling.
Highly Cited
1995
Highly Cited
1995
Phosphoinositide signaling in nuclei of Friend cells: tiazofurin down-regulates phospholipase C beta 1.
Previous investigations have demonstrated the presence of conventional lipid kinases and phospholipase C (PLC) activities in… 
1993
1993
Nucleolar localization of nucleophosmin/B23 requires GTP.
1991
1991
Catabolism of adenine nucleotides in suspension-cultured plant cells.
Highly Cited
1989
Highly Cited
1989
DETECTION OF CLONALLY EXPANDED SALIVARY GLAND LYMPHOCYTES IN SJÖGREN'S SYNDROME
Recurrent swelling of the parotid and submandibular salivary glands occurs in some patients with Sjögren's syndrome (SS). Using… 
Highly Cited
1988
Highly Cited
1988
Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase.
The inhibitory mechanisms of ribavirin 5'-monophosphate (RMP) and thiazole-4-carboxamide adenine dinucleotide (TAD), the active… 
Highly Cited
1988
Highly Cited
1988
Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells.
Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP… 
Highly Cited
1987
Highly Cited
1987
Hematological and biochemical action of tiazofurin (NSC 286193) in a case of refractory acute myeloid leukemia.
A patient with refractory acute myeloid leukemia was treated with tiazofurin, an agent that causes inhibition of tumor cell… 
1987
1987
Colony assay with human tumor xenografts, murine tumors and human bone marrow. Potential for anticancer drug development.
1985
1985
The importance of IMP dehydrogenase inhibition in the broad spectrum antiviral activity of ribavirin and selenazofurin.
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