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The molecular classification of multiple myeloma.
TLDR
A subset of cases with a predominating myeloid gene expression signature had more favorable baseline characteristics and superior prognosis to those lacking this signature, suggesting that this signature is linked to disease progression.
International uniform response criteria for multiple myeloma
TLDR
The European Group for Blood and Bone Marrow Transplant/International Bone Marrows Transplant Registry criteria have been expanded, clarified and updated to provide a new comprehensive evaluation system to adequately assess clinical outcomes in myeloma.
Thalidomide and hematopoietic-cell transplantation for multiple myeloma.
TLDR
When incorporated into high-dose therapy for myeloma, thalidomide increased the frequency of complete responses and extended event-free survival at the expense of added adverse effects without improving overall survival.
Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells.
TLDR
Novel candidate MM disease genes have been identified using gene expression profiling and this profiling has led to the development of a gene-based classification system for MM.
International uniform response criteria for multiple myeloma
Correction to: Leukemia (2006) 20, 1467–1473. doi:10.1038/sj.leu.2404284 It has been identified by the authors that there was an error in the author list. The following author was omitted in error. M
Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation.
TLDR
These consensus guidelines have been compiled with input from the Scientific Advisors of the International Myeloma Foundation to be international in scope, plus provide recommendations for both clinical practice and research approaches.
Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma.
TLDR
Bone marrow aspirates from 306 patients with multiple myeloma were analyzed by flow cytometric immunophenotyping and the combination of CD38 and CD138 was superior to CD38 alone for identifying CD45+myeloma and separating CD20+Myeloma from B-cell lymphoma.
Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and
TLDR
Investigation of amplification of chromosome band 1q21 in patients with monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and newly diagnosed MM revealed that Amp1q21 was an independent poor prognostic factor.
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group
TLDR
The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations to facilitate comparison of therapeutic trial data.
Total therapy with tandem transplants for newly diagnosed multiple myeloma.
TLDR
Time-dependent covariate analysis suggested that timely application of a second transplant extended both EFS and OS significantly, independent of cytogenetics and beta-2-microglobulin.
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