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substance P-saporin

Known as: SP-SAP 
An agent composed of substance P (SP) conjugated to the ribosome-inactivating protein and neurotoxin saporin (SAP), isolated from the seeds of the… 
National Institutes of Health

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Broader (1)

Substance P
analogs & derivatives

Papers overview

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2016
2016
Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4
2009
2009
Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein.
Ribosome inactivating proteins (RIPs) catalyze the hydrolytic depurination of one or more adenosine residues from eukaryotic… 
2008
2008
Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones
2007
2007
Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABAA receptors
2006
2006
Ablation of NK1 receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats
2002
2002
Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors
1999
1999
Retrogradely transported CTB-saporin kills sympathetic preganglionic neurons.
Aiming to ablate sympathetic preganglionic neurons (SPN) innervating a defined target, we injected saporin conjugated to cholera… 
1999
1999
Lesions of the C 1 catecholaminergic neurons of the ventrolateral medulla in rats using anti-D b H-saporin
Madden, Christopher J., Satoru Ito, Linda Rinaman, Ronald G. Wiley, and Alan F. Sved. Lesions of the C1 catecholaminergic neurons… 
Review
1998
Review
1998
Saporin immunotoxins.
1988
1988
Comparison of the pharmacokinetics and hepatotoxic effects of saporin and ricin A-chain immunotoxins on murine liver parenchymal cells.
Immunotoxins containing the ribosome-inactivating protein, saporin, are very effective antitumor agents but are highly toxic to… 
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