substance P-saporin

Known as: SP-SAP 
An agent composed of substance P (SP) conjugated to the ribosome-inactivating protein and neurotoxin saporin (SAP), isolated from the seeds of the… (More)
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND Substance P-saporin (SP-SAP), a chemical conjugate of substance P and a recombinant version of the ribosome… (More)
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2013
2013
BACKGROUND Neurokinin-1 receptors (NK1-rs) located on superficial dorsal horn neurons are essential for integration of… (More)
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2009
2009
Current theories of neuropathic hypersensitivity include an imbalance of supraspinal inhibition and facilitation. Our overall… (More)
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2006
2006
Intrathecal (IT) substance P-Saporin (SP-SAP), a 33-kDa-targeted neurotoxin, produces selective destruction of superficial… (More)
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Highly Cited
2005
Highly Cited
2005
Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to… (More)
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Highly Cited
2002
Highly Cited
2002
In previous studies, we have shown that loss of spinal neurons that possess the substance P receptor (SPR) attenuated pain and… (More)
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Highly Cited
2002
Highly Cited
2002
All medullary central chemoreceptor sites contain neurokinin-1 receptor immunoreactivity (NK1R-ir). We ask if NK1R-ir neurons and… (More)
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Highly Cited
2002
Highly Cited
2002
The expression of cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic hematopoietic cells, both on… (More)
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Highly Cited
1999
Highly Cited
1999
Substance P receptor (SPR)-expressing spinal neurons were ablated with the selective cytotoxin substance P-saporin. Loss of these… (More)
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1999
1999
Neurons expressing neurokinin-1 receptors (NK-1R) are selectively destroyed by substance P (SP) coupled to the ribosome… (More)
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