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Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating proteinExpand
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Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor
192 IgG, a monoclonal antibody to the rat nerve growth factor (NGF) receptor, was disulfide-coupled to saporin, a ribosome-inactivating protein. Systemic injection of 192 IgG-saporin destroyedExpand
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Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation
A family of muscarinic ACh receptor genes are expressed in hippocampus, but little is known about the localization of the encoded proteins and their regulation by cholinergic innervation.Expand
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Hippocampal theta activity following selective lesion of the septal cholinergic systeM
The characteristic electroencephalographic patterns within the hippocampus are theta and sharp waves. Septal neurons are believed to play an essential role in the rhythm generation of the thetaExpand
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Immunolocalization of the cocaine‐ and antidepressant‐sensitive l‐norepinephrine transporter
Norepinephrine (NE) transporters (NETs) constitute the primary mechanism for inactivation of synaptically released NE, are targets for multiple antidepressants and psychostimulants, and have beenExpand
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Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis
The effects on anatomy and behavior of a ribosomal inactivating protein (saporin) coupled to a monoclonal antibody against the low-affinity NGF receptor (NGFr) were examined. In adult rats, NGFr isExpand
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Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats
The behavioral, biochemical, histological, and electrophysiological effects of a basal forebrain injection of saporin, a ribosome- inactivating protein, coupled to a monoclonal antibody against theExpand
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Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings
The ability to create lesions of discrete neuronal populations is an important strategy for clarifying the function of these populations. The power of this approach is critically dependent upon theExpand
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Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats.
Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into either the medial septum andExpand
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Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits
192-IgG saporin is an anti-neuronal immunotoxin that combines the 192 monoclonal antibody to the p75 neurotrophin receptor found on terminals and cell bodies of neurons in the cholinergic basalExpand
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