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spergualin

Known as: Heptanamide, 7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-3-hydroxy- 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Antibiotics, AntineoplasticGuanidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1992
1992
THE SUPPRESSIVE EFFECT OF DEOXYSPERGUALIN ON THE DIFFERENTIATION OF HUMAN B LYMPHOCYTES MATURING INTO IMMUNOGLOBULIN‐PRODUCING CELLS
Deoxyspergualin, an analog of spergualin, has been known as a novel immunosuppressive agent with strong immunosuppressive… 
Highly Cited
1990
Highly Cited
1990
Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.
Immunotoxins are potent cell-killing agents that may be useful in the treatment of cancer. The early production of neutralizing… 
1988
1988
Synthesis and biological activity of spergualin analogues. I.
Stable spergualin analogues were synthesized by substitutions of the alpha-hydroxyglycine residue of spergualin with various… 
1987
1987
Synthesis and antitumor activity of spergualin analogues. II. Chemical modification of the spermidine moiety.
Chemical modifications of the spermidine moiety of an antitumor antibiotic, spergualin (Ia), and the structure-activity… 
1987
1987
Spergualin: a new antitumour antibiotic.
Spergualin was isolated from the culture filtrate of Bacillus laterosporus as an antitumour substance. It had a unique structure… 
1986
1986
Antitumor activity of spergualin, a novel antitumor antibiotic.
Spergualin (SGL), a novel antitumor antibiotic, exhibited strong antitumor activity against transplantable leukemias in mice… 
1986
1986
Induction of antitumor resistance to mouse leukemia L1210 by spergualins.
Spergualin and its analog, 15-deoxyspergualin showed a marked antitumor effect against L1210 by intraperitoneal and oral… 
Highly Cited
1985
Highly Cited
1985
Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety.
Many analogues and derivatives of an antitumor antibiotic, spergualin, were synthesized, and the relationships between the… 
Highly Cited
1982
Highly Cited
1982
Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate.
The method for chemical modification of spergualin with retention of the configuration at the C-11 has been achieved by the use… 
1981
1981
The total synthesis of spergualin, an antitumor antibiotic.
Sir: During our studies of antitumor antibiotics, spergualin was discovered in culture filtrates of a Bacillus strain… 
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