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sipatrigine

Known as: 4-amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine 
National Institutes of Health

Papers overview

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2006
2006
Sipatrigine is a substituted pyrimidine derived from lamotrigine. It attenuates glutamate release in vitro and in vivo, probably… 
Highly Cited
2002
Highly Cited
2002
Alanine-scanning mutagenesis of transmembrane segments IS6 and IIS6 of the rat brain Nav1.2 channel α subunit identified… 
Highly Cited
2002
Highly Cited
2002
The persistent, slowly inactivating fraction of the sodium current is involved in key functions in the CNS such as dendritic… 
Highly Cited
2000
Highly Cited
2000
Background: The sodium channel blocker sipatrigine (619C89) prevents ischemia-induced glutamate release and is neuroprotective in… 
Highly Cited
2000
Highly Cited
2000
BACKGROUND AND PURPOSE The aim of this study was to determinate the possible role of the ionotropic glutamate receptor in the… 
Highly Cited
1993
Highly Cited
1993
Background and Purpose The excitatory amino acid neurotransmitter glutamate is involved in excitotoxic brain injury and…