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sipatrigine

Known as: 4-amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (1)

BW 619C89

Broader (4)

Neuroprotective AgentsNeurotransmitter Uptake InhibitorsPiperazinesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor
Sipatrigine is a substituted pyrimidine derived from lamotrigine. It attenuates glutamate release in vitro and in vivo, probably… 
2004
2004
Sodium channel blocking activity of AM-36 and sipatrigine (BW619C89): in vitro and in vivo evidence
2003
2003
Pharmacology of ischemia-induced glutamate efflux from rat cerebral cortex in vitro
Highly Cited
2001
Highly Cited
2001
A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke
2001
2001
Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92
Highly Cited
2001
Highly Cited
2001
The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK
2001
2001
Effects of extracellular pH on the interaction of sipatrigine and lamotrigine with high-voltage-activated (HVA) calcium channels in dissociated neurones of rat cortex
2001
2001
The role of sodium channels in disease.
Native sodium channels exist as polypeptide multimers of an alpha-subunit (260 kDa) and subsidiary and smaller beta-subunits… 
2000
2000
Electrophysiology of Sipatrigine: A Lamotrigine Derivative Exhibiting Neuroprotective Effects
Sipatrigine (BW619C89), a derivative of the antiepileptic agent lamotrigine, has potent neuroprotective properties in animal… 
2000
2000
Inhibition of recombinant low-voltage-activated Ca2+ channels by the neuroprotective agent BW619C89 (Sipatrigine)
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