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Relatively little has been published on the pharmacology of R-type and T-type Ca(2+) channels. Here, whole-cell Ca(2+) channel… Expand Alanine-scanning mutagenesis of transmembrane segments IS6 and IIS6 of the rat brain Nav1.2 channel α subunit identified… Expand Excessive nitric oxide formation may contribute to the pathology occurring in diseases affecting central white matter, such as… Expand We have cloned and functionally expressed the human orthologue of the mouse TRAAK gene. When cDNA for hTRAAK is expressed in… Expand Acidic extracellular pH reduced high-voltage-activated (HVA) currents in freshly isolated cortical pyramidal neurones of adult… Expand Background: The sodium channel blocker sipatrigine (619C89) prevents ischemia-induced glutamate release and is neuroprotective in… Expand BACKGROUND AND PURPOSE
The aim of this study was to determinate the possible role of the ionotropic glutamate receptor in the… Expand T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK 293 cells stably expressing recombinant low-voltage-activated Ca(2… Expand Sipatrigine (BW619C89), a derivative of the antiepileptic agent lamotrigine, has potent neuroprotective properties in animal… Expand Background and Purpose The excitatory amino acid neurotransmitter glutamate is involved in excitotoxic brain injury and… Expand