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sipatrigine

Known as: 4-amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Relatively little has been published on the pharmacology of R-type and T-type Ca(2+) channels. Here, whole-cell Ca(2+) channel… Expand
Highly Cited
2002
Highly Cited
2002
Alanine-scanning mutagenesis of transmembrane segments IS6 and IIS6 of the rat brain Nav1.2 channel α subunit identified… Expand
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Highly Cited
2002
Highly Cited
2002
Excessive nitric oxide formation may contribute to the pathology occurring in diseases affecting central white matter, such as… Expand
Highly Cited
2001
Highly Cited
2001
We have cloned and functionally expressed the human orthologue of the mouse TRAAK gene. When cDNA for hTRAAK is expressed in… Expand
2001
2001
Acidic extracellular pH reduced high-voltage-activated (HVA) currents in freshly isolated cortical pyramidal neurones of adult… Expand
2000
2000
Background: The sodium channel blocker sipatrigine (619C89) prevents ischemia-induced glutamate release and is neuroprotective in… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND AND PURPOSE The aim of this study was to determinate the possible role of the ionotropic glutamate receptor in the… Expand
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2000
2000
T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK 293 cells stably expressing recombinant low-voltage-activated Ca(2… Expand
2000
2000
Sipatrigine (BW619C89), a derivative of the antiepileptic agent lamotrigine, has potent neuroprotective properties in animal… Expand
Highly Cited
1993
Highly Cited
1993
Background and Purpose The excitatory amino acid neurotransmitter glutamate is involved in excitotoxic brain injury and… Expand
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