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sipatrigine
Known as:
4-amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine
National Institutes of Health
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Related topics
Related topics
5 relations
Narrower (1)
BW 619C89
Broader (4)
Neuroprotective Agents
Neurotransmitter Uptake Inhibitors
Piperazines
Pyrimidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.
Lisa A. Clutterbuck
,
C. Posada
,
+5 authors
D. Selwood
Journal of Medicinal Chemistry
2009
Corpus ID: 2751081
We report the discovery of a new class of neuroprotective voltage-dependent sodium channel modulators exemplified by (5-(1-benzyl…
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2006
2006
Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor
A. Hainsworth
,
A. Stefani
,
P. Calabresi
,
T. W. Smith
,
M. Leach
2006
Corpus ID: 71228297
Sipatrigine is a substituted pyrimidine derived from lamotrigine. It attenuates glutamate release in vitro and in vivo, probably…
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2003
2003
Pharmacology of ischemia-induced glutamate efflux from rat cerebral cortex in vitro
R. M. Nelson
,
D. Lambert
,
A. Green
,
A. Hainsworth
Brain Research
2003
Corpus ID: 9919735
Highly Cited
2003
Highly Cited
2003
Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents.
A. Hainsworth
,
N. McNaughton
,
A. Pereverzev
,
T. Schneider
,
A. Randall
European Journal of Pharmacology
2003
Corpus ID: 23174267
Highly Cited
2002
Highly Cited
2002
Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve
G. Garthwaite
,
David A. Goodwin
,
A. Batchelor
,
K. Leeming
,
John Garthwaite
Neuroscience
2002
Corpus ID: 22979092
Highly Cited
2002
Highly Cited
2002
Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons
F. Spadoni
,
A. Hainsworth
,
+5 authors
A. Stefani
NeuroReport
2002
Corpus ID: 46487686
The persistent, slowly inactivating fraction of the sodium current is involved in key functions in the CNS such as dendritic…
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Highly Cited
2001
Highly Cited
2001
A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke
D. Dawson
,
G. Wadsworth
,
A. Palmer
Brain Research
2001
Corpus ID: 8793348
2001
2001
Neuroprotective actions in vivo and electrophysiological actions in vitro of 202W92
L. Caputi
,
A. Hainsworth
,
+7 authors
A. Stefani
Brain Research
2001
Corpus ID: 10351253
Highly Cited
2000
Highly Cited
2000
Phase II Clinical Trial of Sipatrigine (619C89) by Continuous Infusion in Acute Stroke
K. Muir
,
L. Holzapfel
,
K. Lees
Cerebrovascular Diseases
2000
Corpus ID: 13588339
Background: The sodium channel blocker sipatrigine (619C89) prevents ischemia-induced glutamate release and is neuroprotective in…
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2000
2000
Electrophysiology of Sipatrigine: A Lamotrigine Derivative Exhibiting Neuroprotective Effects
P. Calabresi
,
A. Stefani
,
+7 authors
G. Bernardi
Experimental Neurology
2000
Corpus ID: 24506622
Sipatrigine (BW619C89), a derivative of the antiepileptic agent lamotrigine, has potent neuroprotective properties in animal…
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