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sipatrigine

Known as: 4-amino-2-(4-methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)pyrimidine 
 
National Institutes of Health

Papers overview

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2008
2008
Major depressive disorder (MDD) is a chronic, recurring and potentially life-threatening mental illness. Current treatments are… Expand
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2003
2003
Relatively little has been published on the pharmacology of R-type and T-type Ca(2+) channels. Here, whole-cell Ca(2+) channel… Expand
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Highly Cited
2002
Highly Cited
2002
Alanine-scanning mutagenesis of transmembrane segments IS6 and IIS6 of the rat brain Na(v)1.2 channel alpha subunit identified… Expand
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Highly Cited
2002
Highly Cited
2002
Excessive nitric oxide formation may contribute to the pathology occurring in diseases affecting central white matter, such as… Expand
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2002
2002
The persistent, slowly inactivating fraction of the sodium current is involved in key functions in the CNS such as dendritic… Expand
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2001
2001
We have cloned and functionally expressed the human orthologue of the mouse TRAAK gene. When cDNA for hTRAAK is expressed in… Expand
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2001
2001
Acidic extracellular pH reduced high-voltage-activated (HVA) currents in freshly isolated cortical pyramidal neurones of adult… Expand
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2001
2001
There are many examples of compounds showing neuroprotective efficacy in animal models of stroke but not in clinical trials. It… Expand
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2000
2000
Background: The sodium channel blocker sipatrigine (619C89) prevents ischemia-induced glutamate release and is neuroprotective in… Expand
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1993
1993
BACKGROUND AND PURPOSE The excitatory amino acid neurotransmitter glutamate is involved in excitotoxic brain injury and… Expand
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