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Experimental models of vascular dementia and vascular cognitive impairment: a systematic review
J. Neurochem. (2010) 115, 814–828.
Do in vivo Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review
TLDR
A systematic review of animal models of SVD determined whether these resemble four key clinicopathologic features: small, discrete infarcts; small vessel arteriopathy; diffuse white matter damage; cognitive impairment; chronic hypertensive models; and the stroke-prone spontaneously hypertensive rat (SHR-SP). Expand
Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons
TLDR
Given the damaging role of a sustained influx of sodium in both pharmaco-resistant seizures or excitotoxic insults, it is suggested the utilization of drugs that suppress the persistent conductance. Expand
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke
TLDR
The evidence that GABAergic function is acutely depressed following an ischaemic insult is examined, and the data that suggest that increasing cerebral GABA concentration has a neuroprotective effect, as does the administration of some (but not all) GABAmimetic agents are reviewed. Expand
Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients
TLDR
Elevated cGMP extracellular concentrations in the internal segment of the globus pallidus are found, despite negligible changes in glutamate levels, during a clinically effective STN‐DBS, supporting the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi. Expand
Post-mortem assessment in vascular dementia: advances and aspirations
TLDR
Elucidation of the pathophysiology of cerebrovascular disease, clarification of characteristic findings of in vivo imaging and knowledge about the impact of combined pathologies are needed to improve the diagnostic accuracy of clinical diagnoses. Expand
Activation of recombinant human TRPV1 receptors expressed in SH‐SY5Y human neuroblastoma cells increases [Ca2+]i, initiates neurotransmitter release and promotes delayed cell death
TLDR
The establishment of the first neuronal model expressing recombinant human TRPV1, a ligand‐gated, Ca2+‐permeable ion channel in the TRP superfamily of channels, which displays pharmacology consistent with TRpV1 heterologously expressed in standard non‐neuronal cells and native neuronal cultures is reported. Expand
Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population.
TLDR
It is concluded that capsaicin, anandamide, and NADA can initiate TRPV1-dependent delayed cell death in neurone-like cells, an apoptosis-like process, but independent of caspase activity. Expand
The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain
Serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) protects neuronal cells from injury stimuli in vitro, and exerts anti‐apoptotic effects via downstream targets including the forkhead‐likeExpand
Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).
TLDR
Extensive clinical and preclinical data support HCy as a mediator for VCID, and further trials of combined B-vitamin supplementation are called for, incorporating lessons from previous trials and from recent experimental work. Expand
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