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Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia
Long-term treatment with the dopamine precursor levodopa (L-DOPA) induces dyskinesia in Parkinson's disease (PD) patients. We divided hemiparkinsonian rats treated chronically with L-DOPA into twoExpand
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Long-term synaptic depression in the striatum: physiological and pharmacological characterization
The effect of tetanic activation of corticostriatal glutamatergic fibers was studied in striatal slices by utilizing extracellular and intracellular recording techniques. Tetanic stimulation producedExpand
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Dopamine-mediated regulation of corticostriatal synaptic plasticity
The striatum represents the main input into the basal ganglia. Neurons projecting from the striatum receive a large convergence of afferents from all areas of the cortex and transmit neuralExpand
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Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity
A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatalExpand
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Long‐term Potentiation in the Striatum is Unmasked by Removing the Voltage‐dependent Magnesium Block of NMDA Receptor Channels
We have studied the effects of tetanic stimulation of the corticostriatal pathway on the amplitude of striatal excitatory synaptic potentials. Recordings were obtained from a corticostriatal sliceExpand
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Direct and indirect pathways of basal ganglia: a critical reappraisal
The basal ganglia are subcortical nuclei controlling voluntary actions and have been implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function states that two circuits,Expand
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Saccade preparation inhibits reorienting to recently attended locations.
We measured manual reaction time in normal human subjects to confirm that an eccentric visual signal has a biphasic effect on covert attention and eye movements. First, it summons attention andExpand
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Acetylcholine-mediated modulation of striatal function
Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target ofExpand
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Dopaminergic control of synaptic plasticity in the dorsal striatum
Cortical glutamatergic and nigral dopaminergic afferents impinge on projection spiny neurons of the striatum, providing the most significant inputs to this structure. Isolated activation of glutamateExpand
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Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
Dopamine D2 receptors (D2Rs) are of crucial importance in the striatal processing of motor information received from the cortex. Disruption of the D2R gene function in mice results in a severeExpand
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