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Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.
Gait disturbances and akinesia are extremely disabling in advanced Parkinson's disease. It has been suggested that modulation of the activity of the pedunculopontine nucleus (PPN) may be beneficialExpand
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Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues.
OBJECTIVE To provide recommendations to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD). DATA SOURCES ANDExpand
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Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease
The peduncolopontine nucleus modulates locomotor activity and dysfunction in this nucleus may be responsible for the gait and postural impairments seen in Parkinson's disease and other movementExpand
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Properties of the Hyperpolarization‐activated Cation Current lh in Rat Midbrain Dopaminergic Neurons
Intracellular electrophysiological recordings in current‐ and voltage‐clamp mode were obtained from dopaminergic neurons of the rat mesencephalon in an in vitro slice preparation. In current‐clampExpand
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Dopamine receptor subtypes colocalize in rat striatonigral neurons.
Dopaminergic neurons of the substantia nigra provide one of the major neuromodulatory inputs to the neostriatum. Recent in situ hybridization experiments have suggested that postsynaptic dopamineExpand
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Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones
1 The effects of the dihydropyridine calcium channel antagonists, nifedipine and nimodipine (300 nm‐30 μm) were tested in vitro on intracellularly recorded dopaminergic neurones in the rat ventralExpand
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Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease
To understand the events underlying the clinical efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN), electrophysiological recordings and microdialysis evaluations were carriedExpand
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Lowered cAMP and cGMP signalling in the brain during levodopa‐induced dyskinesias in hemiparkinsonian rats: new aspects in the pathogenetic mechanisms
Dysregulation of dopamine receptors is thought to underlie levodopa‐induced dyskinesias in experimental models of Parkinson’s disease. It is unknown whether an imbalance of the second messengers,Expand
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Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature.
One objective of modern neuroimaging is to identify markers that can aid in diagnosis, disease progression monitoring and long-term drug impact analysis. In this study, Parkinson-associatedExpand
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Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: Evidence for D1 receptor involvement
Intracellular recordings were obtained from rat neostriatal slices. Bath-applied dopamine (1-10 microM) produced a reversible inhibition of the action potentials evoked by direct stimulation and aExpand
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