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silybin

Known as: silibin, silibinin, silybinin 
National Institutes of Health

Related topics

Related topics

9 relations
2,3-dehydrosilybin

Broader (5)

Antineoplastic AgentsAntioxidantsFlavonoidsPlant Extracts

Narrower (3)

Hepar-PascHepatosLagosa

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Investigation of the interactions of silibinin with 2-hydroxypropyl-β-cyclodextrin through biophysical techniques and computational methods.
Cyclodextrins (CDs) are a well-known class of supermolecules that have been widely used to protect drugs against conjugation and… 
Review
2014
Review
2014
Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials
Objective. This study aimed to evaluate the efficacy and safety of silymarin on chronic hepatitis C virus- (HCV-) infected… 
Highly Cited
2012
Highly Cited
2012
Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway.
The activation of epidermal growth factor (EGF) through its receptor, EGFR, is one of the major mechanisms that… 
2012
2012
Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and…
Metastasis is a property of malignant cancer cells that requires integrins which with their downstream molecules participate in a… 
Highly Cited
2012
Highly Cited
2012
Silibinin Attenuates Sulfur Mustard Analog-Induced Skin Injury by Targeting Multiple Pathways Connecting Oxidative Stress and Inflammation
Chemical warfare agent sulfur mustard (HD) inflicts delayed blistering and incapacitating skin injuries. To identify effective… 
Highly Cited
2011
Highly Cited
2011
Chemopreventive and Chemotherapeutic Effects of Intravesical Silibinin against Bladder Cancer by Acting on Mitochondria
Intravesical chemotherapy is often used to prevent the recurrence of superficial bladder cancer after transurethral resection. A… 
Highly Cited
2010
Highly Cited
2010
Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway.
Hepatoprotectant silibinin has anticancer and chemo-preventive effects. In this study, silibinin showed significant inhibitory… 
Highly Cited
2003
Highly Cited
2003
Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes.
An increasing incidence of human skin cancer and other adverse effects of solar ultraviolet (UV) radiation enhance the need for… 
Highly Cited
2003
Highly Cited
2003
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
Highly Cited
1995
Highly Cited
1995
[The solubility and bioequivalence of silymarin preparations].
Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular… 
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