Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI

@article{Dastpeyman2011InhibitionOS,
  title={Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI},
  author={Mohadeseh Dastpeyman and Nasrin Motamed and Kayhan Azadmanesh and Ehsan Mostafavi and Vahid Kia and Ali Jahanian-Najafabadi and Mohammad Ali Shokrgozar},
  journal={Medical Oncology},
  year={2011},
  volume={29},
  pages={2512-2518}
}
Metastasis is a property of malignant cancer cells that requires integrins which with their downstream molecules participate in a number of signaling events in cells with pivotal roles in malignancy, migration and invasion of tumor cells. Silibinin, a flavonoid antioxidant from milk thistle (Silybum marianum L.), has attracted attention in the last decades for chemoprevention and chemotherapy of tumor cells. In the present study, the effect of silibinin on migration and adhesion capacity of MDA… CONTINUE READING

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