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Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community
TLDR
This review discusses problems of using morphology alone in the identification of fungi to the species level, the three nuclear ribosomal genes most commonly used in fungal identification, and the potential advantages and limitations of the ITS region. Expand
Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project
TLDR
There was a significant linear correlation between antioxidant activity and total phenolic content for aqueous and methanolic extracts, suggesting that phenolic compounds were the predominant antioxidant components in the investigated plant species. Expand
Camptothecin and taxol: historic achievements in natural products research.
TLDR
This review offers an integrated account of the research team of "Wall and Wani" and the significance of their discoveries to chemistry, biology, and clinical medicine. Expand
Fungal Planet description sheets: 371–399
TLDR
Several novelties are introduced from Spain, namely Psathyrella complutensis on loamy soil, Chlorophyllum lusitanicum on nitrified grasslands and Pseudobeltrania ocoteae from Ocotea obtusata (Beltraniaceae emend.). Expand
Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.
TLDR
Bioactivity-directed fractionation of the leaves of Annona muricata resulted in the isolation of annopentocins A, B, and C(3), and cis- and trans-annomuricin-D-ones (4, 5), and new mono-THF ring acetogenins bearing two flanking hydroxyls and an erythro-diol located between the THF and the ketolactone rings. Expand
Recent advances in Annonaceous acetogenins.
TLDR
Hough most acetogenins have high potencies among several solid human tumour cells lines, some of the derivatives within the different structural types and some positional isomers show remarkable selectivities among certain cell lines, e.g. against prostate cancer (PC-3). Expand
Identification of hepatoprotective flavonolignans from silymarin
TLDR
The data suggest that sily marin- and silymarin-derived compounds may influence HCV disease course in some patients. Expand
Milk Thistle Nomenclature: Why It Matters in Cancer Research and Pharmacokinetic Studies
TLDR
Clinicians and preclinical investigators alike are urged to exercise rigor in nomenclature and use pure compounds or precisely defined chemical mixtures in subsequent studies of milk thistle extracts. Expand
Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
TLDR
Silymarin and silibinin were shown for the first time to suppress the activity of the DNA topoisomerase IIalpha gene promoter in DU145 cells and, among the pure compounds, isosilybin B was again the most effective. Expand
Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma
TLDR
Romidepsin (Istodax), a selective inhibitor of histone deacetylases (HDACs), was approved for the treatment of cutaneous T-cell lymphoma in November 2009 by the US Food and Drug Administration and analogs are sought to create synthetically accessible alternatives. Expand
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