Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

saracatinib

Known as: 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, N-(5-Chloro-1,3-Benzodioxol-4-Yl)-7-(2-(4-Methylpiperazin-1-yl)Ethoxy)-5-((Oxan-4-yl)Oxy)Quinazolin-4-Amine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine 
An orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the developed countries. There is no… Expand
  • table 1
  • table 2
  • figure 1
Is this relevant?
2015
2015
IntroductionDespite significant progress, a disease-modifying therapy for Alzheimer’s disease (AD) has not yet been developed… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Review
2015
Review
2015
The physiological Src proto-oncogene is a protein-tyrosine kinase that plays key roles in cell growth, division, migration, and… Expand
Is this relevant?
Highly Cited
2013
Highly Cited
2013
The phenotypic transformation of well-differentiated epithelial carcinoma into a mesenchymal-like state provides cancer cells… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
BACKGROUND SRC activation is associated with cell migration, proliferation, and metastasis. Saracatinib is an oral tyrosine… Expand
Is this relevant?
Highly Cited
2010
Highly Cited
2010
There is overwhelming evidence that tyrosine kinases play an important role in cancer development. As a prototype of targeted… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Src is a nonreceptor tyrosine kinase thought to be essential for osteoclast function and bone resorption. We investigated the… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2010
2010
The hematogenous metastatic spread of prostate cancer is preferentially to bone and can result in significant patient morbidity… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2009
2009
Elevated Src kinase activity is linked to the progression of solid tumors, including head and neck squamous cell carcinoma (HNSCC… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. We report… Expand
Is this relevant?