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REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.
This work developed REVEL (rare exome variant ensemble learner), an ensemble method for predicting the pathogenicity of missense variants on the basis of individual tools: MutPred, FATHMM, VEST, PolyPhen, SIFT, PROVEAN, MutationAssessor, LRT, GERP, SiPhy, phyloP, and phastCons. Expand
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295. Expand
Multiple loci identified in a genome-wide association study of prostate cancer
The findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals. Expand
Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43.
There is genetic predisposition associated with >=10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric andExpand
Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways
The authors evaluated the association between polymorphisms in genes involved in the androgen biosynthesis and metabolism pathway and the risk of prostate carcinoma. Expand
Functional expression of sv40 in normal human prostatic epithelial and fibroblastic cells - differentiation pattern of nontumorigenic cell-lines.
None of the cell lines analysed showed any tumourigenicity in nude mice over a period of 12 months, similar to the high apoptotic rate observed ipl vivo for normal prostate, particularly after castration should lead to a better understanding of the biology of the different cell compartments involved in the progression of prostate towards neoplasia. Expand
A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma.
A meta-analysis of available data identified significant predictors of IVR that should be systematically assessed to propose a risk-adapted approach to adjuvant intravesical instillation of chemotherapy and cystoscopic surveillance after RNU. Expand
Immortalization of human adult normal prostatic epithelial cells by liposomes containing large T-SV40 gene.
For the first time to the authors' knowledge, the immortalization of normal adult prostatic epithelial cells in culture by transfection of a plasmid containing SV40 genome with a defective replication origin encapsulated into liposomes is reported. Expand
Tubulocystic carcinoma of the kidney: a new entity among renal tumors
Tubulocystic carcinoma should be considered as a new subtype of renal cell carcinoma in the next revision of the World Health Organization (WHO) classification of renal tumors. Expand
FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours.
FGFR3 mutation status might be used to select patients with invasive UCC who have a lower risk of death and is associated with low-stage tumours and a milder disease course in bladder, ureter, and renal pelvis tumours. Expand