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roscovitine

Known as: (2R)-2-((6-benzylamino-9-(propan-2-yl)-9h-purin-2-yl)amino)butan-1-ol, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Antineoplastic AgentsProtein Kinase InhibitorsPurines

Narrower (3)

CYC 202R-roscovitineSeliciclib

Papers overview

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2009
2009
Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic–urethra reflex activity in rats
Highly Cited
2009
Highly Cited
2009
Seliciclib (CYC202, R‐roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model
We sought to determine whether seliciclib (CYC202, R‐roscovitine) could increase the antitumor effects of doxorubicin, with no… 
Highly Cited
2005
Highly Cited
2005
Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.
We reported recently that roscovitine arrested human MCF-7 cancer cells at G2-M phase of the cell cycle and concomitantly induced… 
Highly Cited
2005
Highly Cited
2005
Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse.
R-roscovitine (seliciclib, CYC202) is a cyclin-dependent kinase inhibitor currently in phase II clinical trials in patients with… 
Highly Cited
2004
Highly Cited
2004
Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in many glioma cell lines… 
2003
2003
Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells.
Highly Cited
2003
Highly Cited
2003
Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo.
Frequent deregulation of cyclin-dependent kinase (CDK) activation associated with loss of cell cycle control was found in most of… 
Highly Cited
2002
Highly Cited
2002
Synthesis and biological activity of olomoucine II.
Highly Cited
2001
Highly Cited
2001
Bovine oocytes treated prior to in vitro maturation with a combination of butyrolactone I and roscovitine at low doses maintain a normal developmental capacity
Butyrolactone I (BL‐I) and Roscovitine (ROS), two specific and potent inhibitors of M‐phase promoting factor (MPF) kinase… 
Highly Cited
2000
Highly Cited
2000
Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
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