roscovitine

Known as: (2R)-2-((6-benzylamino-9-(propan-2-yl)-9h-purin-2-yl)amino)butan-1-ol, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine 
 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a… (More)
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Highly Cited
2007
Highly Cited
2007
Seliciclib (CYC202; R-roscovitine) is the first selective, orally bioavailable inhibitor of cyclin-dependent kinases 1, 2, 7 and… (More)
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Highly Cited
2006
Highly Cited
2006
Polycystic kidney diseases (PKDs) are primarily characterized by the growth of fluid-filled cysts in renal tubules leading to end… (More)
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Highly Cited
2005
Highly Cited
2005
(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a… (More)
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Highly Cited
2005
Highly Cited
2005
Seliciclib (CYC202, R-roscovitine) is a cyclin-dependent kinase (CDK) inhibitor that competes for the ATP binding site on the… (More)
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Highly Cited
2003
Highly Cited
2003
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective… (More)
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Highly Cited
2003
Highly Cited
2003
When induced to differentiate, growth-arrested 3T3-L1 preadipocytes synchronously reenter the cell cycle and undergo mitotic… (More)
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Highly Cited
2002
Highly Cited
2002
CDK2 inhibitors have been proposed as effective anti-cancer therapeutics. We show here that CYC202 (R-roscovitine) is a potent… (More)
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Highly Cited
2002
Highly Cited
2002
Nuclear transfer to produce cattle is inefficient because 1) donor cells are not easily synchronized in the proper phase of the… (More)
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Highly Cited
1997
Highly Cited
1997
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These… (More)
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