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R-roscovitine

 
National Institutes of Health

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2015
2015
CONTEXT Cushing disease, due to pituitary corticotroph tumor ACTH hypersecretion, drives excess adrenal cortisol production with… Expand
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2012
2012
Bacterial pneumonia remains associated with high morbidity and mortality. The gram-positive pathogen Streptococcus pneumoniae is… Expand
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2012
2012
The study was carried out in order to evolve, adopt and optimize the new system for preparation of nuclear recipient cells at… Expand
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2011
2011
BACKGROUND Eosinophils are pro-inflammatory cells implicated in the pathogenesis of asthma and atopy. Apoptosis has been proposed… Expand
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2010
2010
BackgroundCDK-inhibitors can diminish transcriptional levels of cell cycle-related cyclins through the inhibition of E2F family… Expand
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2009
2009
Among thyroid carcinomas, highly aggressive undifferentiated or anaplastic carcinomas still await effective therapeutic… Expand
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2008
2008
Seliciclib (CYC202, R-Roscovitine) is a 2, 6, 9-substituted purine analog that is currently in phase II clinical trials as an… Expand
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2005
2005
R-roscovitine (seliciclib, CYC202) is a cyclin-dependent kinase inhibitor currently in phase II clinical trials in patients with… Expand
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Highly Cited
2005
Highly Cited
2005
Cyclin-dependent kinase (CDK) inhibitors have the potential to induce cell-cycle arrest and apoptosis in cancer cells. Seliciclib… Expand
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2004
2004
OBJECTIVE To characterize the pharmacokinetics of R-roscovitine, a novel cyclin-dependent kinase inhibitor, and its carboxylate… Expand
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