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Adoptive transfer and selective reconstitution of streptamer‐selected cytomegalovirus‐specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell
BACKGROUND: Cytomegalovirus (CMV) disease constitutes a serious complication after allogeneic stem cell transplantation. For the clearance of CMV, CD8+ T cells are pivotal.
Antiviral treatment of cytomegalovirus infection and resistant strains.
New antiviral agents are urgently needed with less adverse effects, good oral bioavailability and possibly novel targets or mechanisms of action to avoid cross-resistance and to improve the ability to suppress the selection of resistant virus strains by combination therapy. Expand
Identification of the First Nonpeptidergic Inverse Agonist for a Constitutively Active Viral-encoded G Protein-coupled Receptor*
A small nonpeptidergic molecule (VUF2274) is identified that inhibits US28-mediated phospholipase C activation in transiently transfected COS-7 cells and in HCMV-infected fibroblasts and inhibits HIV entry into cells, providing an important tool to investigate the relevance of US28 constitutive activity in viral pathogenesis. Expand
Human Cytomegalovirus-Induced NKG2Chi CD57hi Natural Killer Cells Are Effectors Dependent on Humoral Antiviral Immunity
It is demonstrated that NKG2Chi CD57hi NK cells are intrinsically responsive to signaling through CD16 cross-linking, and the activity of pathogen-induced innate immune cells can be enhanced by adaptive humoral immunity. Expand
Active Cytomegalovirus Infection in Patients with Septic Shock
Cytomegalovirus reactivation occurred in one third of patients and was associated with prolonged ventilation and stay in an intensive care unit.
Major Tegument Protein pp65 of Human Cytomegalovirus Is Required for the Incorporation of pUL69 and pUL97 into the Virus Particle and for Viral Growth in Macrophages
It is concluded that pp65 is required for the incorporation of other viral proteins into the virus particle and thus is involved in the protein-protein interaction network leading to normal tegument formation. Expand
HCV and HGV in B-cell non-Hodgkin's lymphoma.
HCV seems to have no significance for the pathogenesis of non-Hodgkin's lymphoma in Germany and chemotherapy does not seem to affect the subsequent clinical course of HGV infection. Expand
The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase.
The temporal expression of the UL97 gene product during human cytomegalovirus infection of human foreskin fibroblasts and subcellular localization of this protein were analyzed and it was concluded that UL97 is an early-late gene, requiring DNA replication for maximum expression. Expand
Constitutive Inositol Phosphate Formation in Cytomegalovirus-Infected Human Fibroblasts Is due to Expression of the Chemokine Receptor Homologue pUS28
The results showed that infection of human fibroblasts with all three HCMV strains led to a vigorous, constitutively enhanced formation of inositol phosphates which was insensitive to pertussis toxin. Expand
Human Cytomegalovirus Tegument Proteins ppUL82 (pp71) and ppUL35 Interact and Cooperatively Activate the Major Immediate-Early Enhancer
An important role for the tegument protein ppUL82 in the stimulation of viral immediate-early gene expression and viral infection is suggested. Expand