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(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray
Spinal SIRPα1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats
Spinal Serum-Inducible and Glucocorticoid-Inducible Kinase 1 Mediates Neuropathic Pain via Kalirin and Downstream PSD-95-Dependent NR2B Phosphorylation in Rats
- Hsien-Yu Peng, Gin-Den Chen, Cheng-Yuan Lai, M. Hsieh, Tzer-Bin Lin
- BiologyThe Journal of Neuroscience
- 20 March 2013
It is suggested that nerve injury could induce spinal SGK1 phosphorylation that subsequently interacts with and upregulates kalirin to participate in neuropathic pain development via PSD-95–NR2B coupling-dependent NR2Bosphorylation.
Protein Kinase A–dependent Spinal &agr;-Amino-3-hydroxy-5-methyl-4-isoxazoleproprionate–receptor Trafficking Mediates Capsaicin-induced Colon-Urethra Cross-organ Reflex Sensitization
Delivery of AMPAR-containing Glu receptor 1 subunits to the membranes of lumbosacral DH neurons through a PKA-dependent pathway contributes to noxious stimulation-induced synaptic strengthening, which plays roles in colon-urethra reflex sensitization.
Establishing a standardized therapeutic testing protocol for spinal muscular atrophy
Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus and NMDA-dependent pelvic-urethra reflex activity.
- Hsien-Yu Peng, Pei-chen Huang, Tzer-Bin Lin
- Medicine, BiologyAmerican journal of physiology. Endocrinology and…
- 24 June 2008
The results suggest that estrogen levels might modulate the cross-organ sensitization between the uterus and the urethra and underlie the high concurrence of pelvic pain syndrome and LUT dysfunctions.
TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.
- Hsien-Yu Peng, Hung-Ming Chang, Tzer-Bin Lin
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 1 November 2008
It is demonstrated that TRPV1 plays a crucial role in contributing to the capsaicin-sensitive primary afferent fibers mediating the glutamatergic NMDA-dependent cross-organ sensitization between the uterus and the lower urinary tract when there is a tissue injury.
Melatonin impedes Tet1‐dependent mGluR5 promoter demethylation to relieve pain
It is shown that spinal Tet1 gene transfer by intrathecal delivery of Tet1‐encoding vectors to naïve rats produced profound and long‐lasting nociceptive hypersensitivity and melatonin relieves pain by impeding Tet1-dependent demethylation of mGluR5 in dorsal horn neurons through the MT2 receptor.
Impairment of cerebral hemodynamic response to the cold pressor test in patients with Parkinson's disease.
Attenuation of the extract from Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats.
- Kang Chen, Yi-Jui Chen, Mei-Jung Chen
- Chemistry, MedicineThe Chinese journal of physiology
- 1 February 2012
The MO extract successfully attenuated the development of PH via direct vasodilatation and a potential increase in antioxidant activity as well as chronic treatments with the MO extract reversed the MCT-induced changes.