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Abstract—ACE inhibitors block B2 receptor desensitization, thereby potentiating bradykinin beyond blocking its hydrolysis… Expand BACKGROUND
Endothelial cells (ECs) represent the critical cellular element responsible for postnatal angiogenesis. Because ACE… Expand BACKGROUND
Chronic heart failure (CHF) is associated with endothelial dysfunction, including impaired flow-dependent (endothelium… Expand The beneficial therapeutic effects of angiotensin-converting enzyme (ACE) inhibitors are the result of reduced angiotensin II… Expand BACKGROUND
The angiotensin-converting enzyme (ACE) not only generates angiotensin II but is also the main enzyme that destroys… Expand Mesangial cell growth and accumulation of extracellular matrix proteins constitute key features of progressive glomerular injury… Expand Objective To assess the respective roles of the antihypertensive and blood pressure-independent effects of angiotensin converting… Expand The angiotensin I (AI) metabolite, A(1–7), elicited a concentration‐dependent dilator response (ED50 ≥ 2 μm) in porcine coronary… Expand Trandolapril is a non-sulfhydryl prodrug which, after oral administration, is hydrolysed in the liver to its active diacid… Expand There is increasing evidence that inhibition of tissue angiotensin converting enzyme (ACE) is important for the pharmacokinetics… Expand