Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization.
Findings indicate that postnatal neovascularization does not rely exclusively on sprouting from preexisting blood vessels (angiogenesis); instead, EPCs circulate from bone marrow to incorporate into and thus contribute to postnatal physiological and pathological neov vascularization, which is consistent with postnatal vasculogenesis.
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.
- C. Kalka, H. Masuda, T. Asahara
- Biology, MedicineProceedings of the National Academy of Sciences…
- 28 March 2000
Ex vivo expanded hEPCs may have utility as a "supply-side" strategy for therapeutic neovascularization in mice with hindlimb ischemia and the rate of limb loss was significantly reduced.
VEGF contributes to postnatal neovascularization by mobilizing bone marrow‐derived endothelial progenitor cells
A novel role is established for VEGF in postnatal neovascularization which complements its known impact on angiogenesis and is based on data from animal models and human subjects.
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
Findings indicate that circulating EPCs are mobilized endogenously in response to tissue ischemia or exogenously by cytokine therapy and thereby augment neovascularization of ischemic tissues.
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
A novel role for Shh is revealed as an indirect angiogenic factor regulating expression of multiple angiogenesis cytokines and potential therapeutic use for ischemic disorders is indicated.
Stromal Cell–Derived Factor-1 Effects on Ex Vivo Expanded Endothelial Progenitor Cell Recruitment for Ischemic Neovascularization
It is indicated that locally delivered SDF-1 augments vasculogenesis and subsequently contributes to ischemic neovascularization in vivo by augmenting EPC recruitment in isChemic tissues.
Mouse model of angiogenesis.
- T. Couffinhal, M. Silver, L. Zheng, M. Kearney, B. Witzenbichler, J. Isner
- BiologyAmerican Journal of Pathology
- 30 May 1998
Sequential characterization of the in vivo, histological, and molecular findings in this novel animal model document the role of VEGF as endogenous regulator of angiogenesis in the setting of tissue ischemia and represent a potential means for studying the effects of gene targeting on nutrient angiogenic in vivo.
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
It is suggested that defective endothelial NO synthesis may limit angiogenesis in patients with endothelial dysfunction related to atherosclerosis, and that oral L-arginine supplementation constitutes a potential therapeutic strategy for accelerating angiogenic in Patients with advanced vascular obstruction.
Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia
Ex vivo expanded EPCs incorporate into foci of myocardial neovascularization and have a favorable impact on the preservation of left ventricular function.