International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
- D. Hoyer, D. Clarke, P. Humphrey
- BiologyPharmacological Reviews
- 1 June 1994
It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy.
- P. Tfelt-Hansen, P. de Vries, P. Saxena
- MedicineDrugs
- 2000
Rizatriptan with its shorter time to maximum concentration (tmax) tended to produce a quicker onset of headache relief than sum atriptan and zolmitriptan, and the place of triptans compared with non-triptan drugs in migraine therapy remains to be established and further RCTs are required.
Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism.
- A. Danser, M. Schalekamp, H. Schunkert
- Medicine, BiologyCirculation
- 15 September 1995
Elevated cardiac ACE activity in subjects who died of noncardiac disorders may result in increased cardiac angiotensin II levels, and this may be a mechanism underlying the reported association between the ACE deletion polymorphism and the increased risk for several cardiovascular disorders.
Ergotamine in the acute treatment of migraine: a review and European consensus.
- P. Tfelt-Hansen, P. Saxena, P. Goadsby
- Medicine, PsychologyBrain : a journal of neurology
- 2000
Ergotamine, from a medical perspective, is the drug of choice in a limited number of migraine sufferers who have infrequent or long duration headaches and are likely to comply with dosing restrictions.
Angiotensin II Type 2 Receptor–Mediated Vasodilation in Human Coronary Microarteries
- W. Batenburg, I. Garrelds, A. Danser
- Medicine, BiologyCirculation
- 18 May 2004
AT2 receptor–mediated vasodilation in the human heart appears to be limited to coronary microarteries and is mediated by B2 receptors and NO.
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
- P. Bradley, G. Engel, P. Saxena
- BiologyNeuropharmacology
- 1 June 1986
Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease.
- A. Kranenburg, W. D. de Boer, H. S. Sharma
- Biology, MedicineAmerican Journal of Respiratory Cell and…
- 2002
Pulmonary vascular remodeling, assessed as the ratio of alpha-smooth muscle actin staining and vascular wall area with the lumen diameter, was increased in large vessels of patients with COPD and was inversely correlated with FEV(1) values (P < 0.007).
On Serotonin and Migraine: A Clinical and Pharmacological Review
- M. Ferrari, P. Saxena
- Biology, MedicineCephalalgia
- 1 June 1993
Stimulation of vascular 5-HT1 receptors, probably located in the vessel wall within the dural vascular bed, may alleviate the headache and associated symptoms, but does not interact with earlier mechanisms within the pathophysiological cascade.
Bradykinin‐induced relaxation of coronary microarteries: S‐nitrosothiols as EDHF?
- W. Batenburg, R. Popp, A. Danser
- BiologyBritish Journal of Pharmacology
- 1 May 2004
The results support the concept that bradykinin‐induced relaxation is mediated via de novo synthesized NO and a non‐NO, endothelium‐derived hyperpolarizing factor (EDHF) in porcine coronary microarteries.
Potential role of female sex hormones in the pathophysiology of migraine.
- Saurabh Gupta, S. Mehrotra, C. Villalón, M. Perusquía, P. Saxena, A. Maassenvandenbrink
- Biology, MedicinePharmacology and Therapeutics
- 1 February 2007
...
...