pyrazolopyrimidine

 
National Institutes of Health

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2013
2013
The emergence of protein kinase D (PKD) as a potential therapeutic target for several diseases including cancer has triggered the… (More)
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2012
2012
The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in… (More)
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Highly Cited
2010
Highly Cited
2010
Calcium-regulated exocytosis is a ubiquitous process in eukaryotes, whereby secretory vesicles fuse with the plasma membrane and… (More)
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Highly Cited
2009
Highly Cited
2009
The mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. While showing… (More)
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Highly Cited
2008
Highly Cited
2008
UNLABELLED The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor, is dramatically… (More)
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Highly Cited
2006
Highly Cited
2006
The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands… (More)
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2004
2004
A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase… (More)
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Highly Cited
2004
Highly Cited
2004
The mechanisms involved in the mechanical loading-induced increase in bone formation remain unclear. In this study, we showed… (More)
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2004
2004
Indiplon (NBI 34060; N-methyl-N-[3-[3-(2-thienylcarbonyl)-pyrazolo[1,5-alpha]pyrimidin-7-yl]phenyl]acetamide), a novel… (More)
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Highly Cited
2003
Highly Cited
2003
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective… (More)
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