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Allopurinol

Known as: 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-, 4-Hydroxypyrazolopyrimidine, 1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one 
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the… 
National Institutes of Health

Related topics

Related topics

41 relations

Narrower (18)

6-aminoallopurinol ribosideAlluralApurinCRMBM solution
Allopurinol 300 MG Oral Tablet [Zyloprim]Allopurinol PillAllopurinol SodiumAllopurinol:MCnc:Pt:Ser/Plas:Qn

Broader (7)

AntimetabolitesAntimetabolites, AntineoplasticEnzyme InhibitorsFree Radical Scavengers

Papers overview

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Highly Cited
1999
Highly Cited
1999
Rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy.
Highly Cited
1998
Highly Cited
1998
Mechanisms of beta cell death in diabetes: a minor role for CD95.
Insulin-dependent diabetes mellitus is an autoimmune disease, under polygenic control, manifested only when >90% of the insulin… 
Highly Cited
1996
Highly Cited
1996
Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.
LBNF1 heart grafts are rejected in an accelerated manner within 36 h by LEW rats that have been sensitized with Brown Norway rat… 
Highly Cited
1988
Highly Cited
1988
Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists.
Highly Cited
1983
Highly Cited
1983
Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.
Highly Cited
1979
Highly Cited
1979
ATYPICAL LEGIONELLA-LIKE ORGANISMS: FASTIDIOUS WATER-ASSOCIATED BACTERIA PATHOGENIC FOR MAN
Highly Cited
1978
Highly Cited
1978
Syngeneic mixed lymphocyte reaction in mice: strain distribution, kinetics, participating cells, and absence in NZB mice.
Co-culture of mouse spleen nonadherent (T-enriched cells with mitomycin C-treated unfractionated syngeneic spleen cells resulted… 
Highly Cited
1975
Highly Cited
1975
Cytotoxic effects of antigen- and mitogen-induced T cells on various targets.
Mitogen-induced cytotoxicity was studied by culturing mouse spleen cells with an optimum mitogenic dose of concanavalin A (Con A… 
Review
1975
Review
1975
Drug-induced systemic lupus erythematosus: a critical review.
Highly Cited
1970
Highly Cited
1970
Impairment of drug metabolism in man by allopurinol and nortriptyline.
Abstract Normal medical students received either allopurinol or nortriptyline. To quantitate changes in rates of drug metabolism… 
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