Allopurinol

Known as: 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-, 4-Hydroxypyrazolopyrimidine, 1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one 
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND OBJECTIVES Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and… (More)
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Highly Cited
2008
Highly Cited
2008
CONTEXT Hyperuricemia is a predictor for the development of hypertension and is commonly present in new-onset essential… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression. Allopurinol… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish its… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for… (More)
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Highly Cited
2005
Highly Cited
2005
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Increased oxidative stress in chronic heart failure is thought to contribute to endothelial dysfunction. Xanthine… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND In patients with chronic heart failure (CHF), hyperuricemia is a common finding and is associated with reduced… (More)
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Highly Cited
2000
Highly Cited
2000
Therapeutic strategies against free radicals have mostly focused on the augmentation of antioxidant defenses (eg, vitamins C and… (More)
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Highly Cited
1987
Highly Cited
1987
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k2 approx. 10(9) M-1 X s-1). One product of attack of… (More)
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