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Allopurinol

Known as: 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-, 4-Hydroxypyrazolopyrimidine, 1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one 
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND OBJECTIVES Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and… Expand
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Highly Cited
2008
Highly Cited
2008
CONTEXT Hyperuricemia is a predictor for the development of hypertension and is commonly present in new-onset essential… Expand
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Review
2006
Review
2006
The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression. Allopurinol… Expand
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Highly Cited
2006
Highly Cited
2006
Background— Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for… Expand
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Highly Cited
2005
Highly Cited
2005
  • S. Hung, W. Chung, +16 authors Y. Chen
  • Proceedings of the National Academy of Sciences…
  • 2005
  • Corpus ID: 13802230
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse… Expand
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Highly Cited
2002
Highly Cited
2002
Background—Increased oxidative stress in chronic heart failure is thought to contribute to endothelial dysfunction. Xanthine… Expand
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Highly Cited
2000
Highly Cited
2000
Therapeutic strategies against free radicals have mostly focused on the augmentation of antioxidant defenses (eg, vitamins C and… Expand
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Review
1985
Review
1985
  • J. McCord
  • The New England journal of medicine
  • 1985
  • Corpus ID: 42717930
It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion… Expand