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BACKGROUND AND OBJECTIVES
Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and… Expand CONTEXT
Hyperuricemia is a predictor for the development of hypertension and is commonly present in new-onset essential… Expand The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and… Expand BACKGROUND
Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression. Allopurinol… Expand Background— Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish… Expand BACKGROUND
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for… Expand Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse… Expand Background—Increased oxidative stress in chronic heart failure is thought to contribute to endothelial dysfunction. Xanthine… Expand Therapeutic strategies against free radicals have mostly focused on the augmentation of antioxidant defenses (eg, vitamins C and… Expand It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion… Expand