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Allopurinol

Known as: 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-, 4-Hydroxypyrazolopyrimidine, 1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one 
A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the… 
National Institutes of Health

Related topics

Related topics

41 relations

Narrower (18)

6-aminoallopurinol ribosideAlluralApurinCRMBM solution
Allopurinol 300 MG Oral Tablet [Zyloprim]Allopurinol PillAllopurinol SodiumAllopurinol:MCnc:Pt:Ser/Plas:Qn

Broader (7)

AntimetabolitesAntimetabolites, AntineoplasticEnzyme InhibitorsFree Radical Scavengers

Papers overview

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Highly Cited
1999
Highly Cited
1999
Upregulation of T-helper 1 cytokines and chemokine expression in post-transplant airway obliteration.
The major obstacle to long-term survival after lung transplantation is chronic graft dysfunction manifest as bronchiolitis… 
Highly Cited
1999
Highly Cited
1999
QUIMIOTERAPIA DE LA ENFERMEDAD DE CHAGAS
Highly Cited
1987
Highly Cited
1987
Use and abuse of allopurinol.
Out of hours investigations are no longer used exclusively for diagnosis leading to urgent treatment. Deleting tests that do not… 
1986
1986
Regulation of the secondary in vitro antibody response by endogenous natural killer cells: kinetics, isotype preference, and non-identity with T suppressor cells.
Our previous studies had demonstrated that depletion of endogenous natural killer (NK) cells resulted in an augmented primary… 
1985
1985
Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity.
: Allopurinol has been shown to decrease the gastro-intestinal and bone marrow toxicity of 5-fluorouracil. In an attempt to… 
1984
1984
Systemic Active Suppression Is Not Necessary for Successful Allopregnancy
ABSTRACT: To investigate the role of systemic suppression during allopregnancy, CBA/J female mice were immunised against H‐2d… 
Highly Cited
1983
Highly Cited
1983
Purine salvage networks in Giardia lamblia
Purine metabolism in Giardia lamblia was investigated by monitoring incorporation of radiolabeled precursors into purine… 
Highly Cited
1981
Highly Cited
1981
T cell clones with dual specificity for M1s and various major histocompatibility complex determinants
A high proportion of T cell clones derived from bulk cultures selected to M1s a,d determinants were found to have joint… 
1977
1977
2-pyridylimidazoles as inhibitors of xanthine oxidase.
A series of 28 4-substituted and 4,5-disubstituted 2-pyridylimidazoles was synthesized and evaluated in vitro for inhibition of… 
Highly Cited
1973
Highly Cited
1973
Kinetic properties and inhibition of orotidine 5'-phosphate decarboxylase. Effects of some allopurinol metabolites on the enzyme.
Abstract The 1- and 7-ribosyl 5'-phosphates of oxipurinol [4,6-dihydroxypyrazolo(3,4-d)pyrimidine] were enzymatically synthesized… 
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