• Publications
  • Influence
Pharmacokinetics of nicotine and 12 metabolites in the rat. Application of a new radiometric high performance liquid chromatography assay.
TLDR
New, longer lasting metabolites that may perform the function of prior exposure to small concentrations of nicotine more sensitively are disclosed, at least in the rat. Expand
Disposition of nicotine and eight metabolites in smokers and nonsmokers: Identification in smokers of two metabolites that are longer lived than cotinine
TLDR
The disposition of a single intravenous dose of 14C‐nicotine was investigated in six cigarette smokers and six nonsmokers, and nicotine and eight metabolites were identified, including two new metabolites: metabolite A (3‐hydroxycotinine glucuronide) and metabolite G (demethyl Cotinine Δ2′,3′ ‐enamine). Expand
Metabolism of nicotine.
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
TLDR
The data suggest that in vivo breath analysis after administration of 14C-amino-antipyrine (aminopyrine) was administered orally to healthy ambulant and nonambulant volunteers and to patients with portal cirrhosis, suggesting that hepatic drug metabolism might be conveniently assessed by a breath analysis technic. Expand
Sexual dimorphism of nicotine metabolism and distribution in the rat. Studies in vivo and in vitro.
TLDR
In female rats the reduced rate of nicotine metabolism, as well as a larger volume of distribution of nicotine, explains in part the reported increased lethality of female compared with male rats. Expand
From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions
TLDR
Se sequencing of the entire human genome, the mapping of common haplotypes of single-nucleotide polymorphisms (SNPs), and cost-effective genotyping technologies leading to genome-wide association (GWA) studies—have combined convincingly in the past several years to demonstrate the requirements needed to separate true associations from the plethora of false positives. Expand
Reduced drug elimination in congestive heart failure. Studies using aminopyrine as a model drug.
TLDR
In patients with CHF hepatic drug-metabolizing activity is imparied, and the volume of distribution of drugs is increased, with consequent retardation in rates of drug elimination. Expand
Bernard B. Brodie and the rise of chemical pharmacology.
Implications for Risk Assessment of Host Factors Causing Large Pharmacokinetic Variations
  • E. Vesell
  • Medicine
  • Toxicology and industrial health
  • 1 October 1985
TLDR
In setting standards for environmental chemicals, EPA and NIOSH have attempted to protect the most sensitive humans and should be encouraged to continue this policy. Expand
The antipyrine test in clinical pharmacology: Conceptions and misconceptions
  • E. Vesell
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1 September 1979
TLDR
A fresh look is taken at the antipyrine test and a critical reassessment of its applications and limitations is warranted. Expand
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