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Pharmacokinetics of nicotine and 12 metabolites in the rat. Application of a new radiometric high performance liquid chromatography assay.
A new radiometric assay for nicotine and 12 of its metabolites disclosed that plasma nicotine and cotinine t1/2 beta were independent of dose after single intraarterial nicotine doses of 0.1, 0.5, orExpand
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Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
Abstract To determine whether hepatic drug metabolism might be conveniently assessed by a breath analysis technic, 4-dimethyl-14C-amino-antipyrine (aminopyrine) was administered orally to healthy a...
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Metabolism of nicotine.
  • 137
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Sexual dimorphism of nicotine metabolism and distribution in the rat. Studies in vivo and in vitro.
Interpretation of sex differences in nicotine metabolism and disposition in rats required studies both in vivo and in vitro to provide both metabolic and pharmacokinetic data. In each of four ratExpand
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  • 4
From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions
This review is dedicated to the memory of our dear friend and colleague Professor Werner Kalow (1916–2008) A brief history of human genetics and genomics is provided, comparing recent progress inExpand
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The antipyrine test in clinical pharmacology: Conceptions and misconceptions
  • E. Vesell
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1 September 1979
Since its introduction 11 years ago,75, 77 the antipyrine test, devised to determine quantitatively the effect of individual environmental factors on hepatic drug‐metabolizing capacity in normalExpand
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Reduced drug elimination in congestive heart failure. Studies using aminopyrine as a model drug.
Aminopyrine disposition was studied in 11 patients with congestive heart failure (CHF) and 15 control patients. The aminopyrine metabolic clearance rate was 29.7 +/- 7.1 ml/min (mean +/- SEM) in theExpand
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Implications for Risk Assessment of Host Factors Causing Large Pharmacokinetic Variations
  • E. Vesell
  • Chemistry, Medicine
  • Toxicology and industrial health
  • 1 October 1985
Normal human subjects vary widely in their capacity to eliminate many drugs and environmental chemicals. These variations range in magnitude from fourfold to fortyfold depending on the drug and theExpand
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Studies on the disposition of antipyrine, aminopyrine, and phenacetin using plasma, saliva, and urine
In normal male subjects, the half‐lives of antipyrine, aminopyrine, or phenacetin were not significantly different from the half‐lives of each drug in saliva. Apparent volumes of distribution (aVd)Expand
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Isozymes of lactic dehydrogenase in human tissues.
  • E. Vesell, A. Bearn
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 March 1961
  • 127
  • 2
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