Pharmacology of adenosine receptors of the rat isolated superior cervical ganglion
- Biology, Chemistry
This study has examined the effect of purines and pyrimidines on the rat superior cervical ganglion in vitro and found adenosine and its analogues produced concentration dependent hyperpolarisations, suggesting that protein kinase C is involved in the interaction ofadenosine with muscarine.
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: Possible involvement of adenosinergic mechanism
- Medicine, BiologyEpilepsy Research
Autoradiographic characterization of high-affinity adenosine A2 receptors in the rat brain
- Biology, ChemistryBrain Research
Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice.
- Biology, PsychologyLife sciences
Differences in adenosine A-1 and A-2 receptor density revealed by autoradiography in methylxanthine-sensitive and insensitive mice
- BiologyPharmacology Biochemistry and Behavior
A safety assessment of fixed combinations of acetaminophen and acetylsalicylic acid, coformulated with caffeine.
- Medicine, BiologyRenal failure
Different therapeutic benefits of ASA, acetaminophen and caffeine appear to outweigh any known risk, and it is doubtful if preventing the availability of these products will significantly affect the role of analgesic abuse/overuse in end-stage renal disease.
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil
- Biology, MedicineBrain Research
Adenosine in Central Nervous System Function
Brain adenosine receptors, like those in other tissues (Williams, 1989), can be delineated into two major subclasses, termed A1 and A2 (Hamprecht and Van Calker, 1985), and differentiated by…
Anxiolytic effect of carbamazepine in the elevated plus-maze: possible role of adenosine
- Biology, PsychologyPsychopharmacology
The present results provide preliminary support for a participation of this neurotransmitter in the anxiolytic action of CBZ, and the combination of an anxiogenic dose with a combination of adenosine receptor antagonist and aminophylline resulted in cancellation of each other effects.
SHOWING 1-10 OF 98 REFERENCES
Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists.
- Chemistry, BiologyProceedings of the National Academy of Sciences of the United States of America
1,3-dipropyl-8-(2-amino-4-chlorophenyl) xanthine, a compound of extraordinary receptor affinity, with a Ki for adenosine A1 receptors of 22 pM, is proposed, which is 4,000,000 times more potent than xanthines itself and 70,000 years more powerful than theophylline.
Adenosine receptors and behavioral actions of methylxanthines.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
The data strongly suggest that the behavioral stimulant effects of methylxanthines involve a blockade of central adenosine receptors.
Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors.
- Biology, ChemistryLife sciences
Pyrazolo[3,4-d]pyrimidines as adenosine antagonists.
- Chemistry, BiologyLife sciences
Characterization of adenosine receptors in isolated cerebral arteries of cat
- Biology, ChemistryBritish journal of pharmacology
The results are compatible with the opinion thatadenosine relaxes cerebral vessels by an action on adenosine A2‐receptors and may be linked to adenylate cyclase and can be antagonized by 8‐phenyl‐theophylline.
Purine receptors in mammalian tissues: pharmacology and functional significance.
- Biology, ChemistryAnnual review of pharmacology and toxicology
There is no evidence that specific anabolic processes form adenosine, distinct from those involved in its general metabolic functions, and the physiological factors regulating the extracellular availability of the nucleoside and its distribution make the development of a "purinergic"hesis of neuromodulation difficult.
Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.
- Chemistry, BiologyJournal of medicinal chemistry
During a search for benzodiazepine receptor modulators, a highly potent adenosine antagonist (CGS 15943) was discovered and the synthesis of 2 and some of its analogues and the structure-activity relationships in four biological test systems are described.
Interactions in the behavioral effects of methylxanthines and adenosine derivatives.
- Biology, PsychologyThe Journal of pharmacology and experimental therapeutics
The behavioral effects of L-PIA appeared to be mediated in the brain and were not secondary to the cardiovascular effects, indicating a difference in the behavioral profile of these two agents.
Xanthine derivatives as adenosine receptor antagonists.
- Biology, ChemistryEuropean journal of pharmacology
Nitrobenzylthioinosine binding in brain: an interspecies study.
- Biology, ChemistryLife sciences