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Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation
TLDR
In vivo, 18F-DPA-714 appears to be an attractive alternative to 11C-PK11195 because of its increased bioavailability in brain tissue and its reduced nonspecific binding, and its labeling with 18F, the preferred PET isotope for radiopharmaceutical chemistry, favors its dissemination and wide clinical use. Expand
Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the V1A Receptor
TLDR
Results show for the first time acute prosocial effects of peripherally injected OT and AVP in laboratory rats, and suggest a commonality of action of OT, AVP, and MDMA in stimulating social behavior that involves V1ARs. Expand
Small animal SPECT and its place in the matrix of molecular imaging technologies.
TLDR
The technology developments and design tradeoffs that led to the current state-of-the-art in SPECT small animal scanning are reviewed and the position SPECT occupies within the matrix of molecular imaging technologies is described. Expand
The Translocator Protein
TLDR
The incomplete characterization of multiple T SPO binding sites and the role of TSPO polymerization suggest that current interpretation of PET data may require further refinement, and this work has highlighted the importance of understanding the interaction of ligands with the protein. Expand
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
TLDR
In vitro and in vivo data indicate that these SCs act as highly efficacious CB receptor agonists with greater potency than Δ(9)-THC and earlier generations of SCs. Expand
Evaluation of the PBR/TSPO Radioligand [18F]DPA-714 in a Rat Model of Focal Cerebral Ischemia
TLDR
Results show that in vivo PET imaging with [18F]DPA-714 provides accurate quantitative information of the time course of PBR/TSPO expression in experimental stroke. Expand
Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome
TLDR
Interestingly, although the net rate of protein synthesis is reduced in aged animals, the analyses indicate that the synthesis of certain proteins such as the vitellogenins increases with age. Expand
DPA-714, a New Translocator Protein–Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization
TLDR
The synthesis, radiofluorination, and pharmacologic evaluation of a new TSPO-specific pyrazolopyrimidine, DPA-714, shows promising in vivo properties and is warranting further investigation. Expand
Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135.
TLDR
In vitro functional activities of SC designer drugs JWH-018, UR-144, PB-22, and APICA, and their respective terminally fluorinated analogues and in vivo in vivo cannabinoid type 1 receptor binding affinity evaluated in rats showed no consistent trend for increased potency of fluorinated SCs over the corresponding des-fluoro SCs in vivo. Expand
Brain inflammation is induced by co-morbidities and risk factors for stroke
TLDR
Pilot data show that patients at risk of stroke may also develop brain inflammation, and chronic peripheral inflammation can drive inflammatory changes in the brain. Expand
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