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The prohormone convertase SPC2 (PC2) participates in the processing of proinsulin, proglucagon, and a variety of other… Expand Glucagon-like peptide-2 (GLP-2) stimulates small intestinal growth through induction of intestinal epithelial proliferation. To… Expand Our laboratory has been using a permeabilized cell system derived from rat anterior pituitary GH cells expressing prosomatostatin… Expand The distribution and extent of glutamate decarboxylase 65 (GAD65) mRNA-labeled neurons that coexpress pre-prosomatostatin mRNA… Expand Mammalian prosomatostatin (PSS) is cleaved at a dibasic Arg-Lys site to produce somatostatin-14 (SS-14) and at monobasic Arg and… Expand Individual neurons containing prosomatostatin mRNA were identified with in situ hybridization histochemistry. Our results… Expand Tissue and secreted forms of rat prosomatostatin and its cleavage products were characterized immunochemically using high… Expand Cleavage of the peptide bonds of preprosomatostatin at basic residues near the carboxyl terminus yields somatostatin-14… Expand The tetradecapeptide hormone somatostatin arises from proteolytic processing of a large precursor, pre-prosomatostatin. Studies… Expand The recently isolated 28-residue sequence of prosomatostatin, a putative somatostatin precursor from pig hypothalamus and… Expand