• Publications
  • Influence
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells.
A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues. Its amino acid sequence was revealed as:Expand
  • 1,726
  • 69
Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes.
A heterologous RIA method for pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38) and a homologous RIA method for a shorter form of PACAP with 27 residues (PACAP27) wereExpand
  • 579
  • 29
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
Somatostatin (SRIF), a hypothalamic inhibitor of pituitary growth hormone (GH) and thyroid-stimulating hormone (TSH) secretion, binds to five distinct receptor (SSTR) subtypes. We therefore testedExpand
  • 286
  • 13
  • PDF
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
The recent molecular cloning of the genes encoding three somatostatin (SRIF) receptor subtypes has allowed for the individual expression of these receptors in mammalian cells and characterization ofExpand
  • 271
  • 12
Super-active analogs of growth hormone-releasing factor (1-29)-amide.
Human pancreatic growth hormone releasing factor (1-29)-amide [hpGRF (1-29)-NH2] and the following analogs: [D-Tyr-1]-hpGRF(1-29)-NH2, [D-Ala-2]-hpGRF(1-29)-NH2, [D-Asp-3]-hpGRF(1-29)-NH2, andExpand
  • 112
  • 9
Presence of highly selective receptors for PACAP (pituitary adenylate cyclase activating peptide) in membranes from the rat pancreatic acinar cell line AR 4‐2J
We characterized highly selective receptors for PACAP, the pituitary adenylate cyclase activating peptide, in the tumoral acinar cell line AR 4‐2J derived from the rat pancreas. PACAP, a novelExpand
  • 118
  • 6
RESPONSES TO ANALOGUES OF GROWTH HORMONE‐RELEASING HORMONE IN NORMAL SUBJECTS, AND IN GROWTH‐HORMONE DEFICIENT CHILDREN AND YOUNG ADULTS
Three analogues of growth hormone‐releasing hormone (GHRH) have been compared in normal subjects. GHRH(1‐29)NH2 is equipotent to GHRH(1‐40); increasing doses from 10‐200 per subject augments theExpand
  • 85
  • 6
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
Aims/hypothesisThe glucose-lowering effect of glucagon-like peptide-1 (GLP-1) is based not only upon its potent insulinotropic actions but also on its ability to restrain glucagon secretion.Expand
  • 194
  • 6
  • PDF
Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.
A series of cyclic somatostatin analogs containing a lanthionine bridge have been subjected to studies of structure-activity relationships. A direct synthesis of the thioether bridged analog (1) ofExpand
  • 85
  • 6
Examination of somatostatin involvement in the inhibitory action of GIP, GLP‐1, amylin and adrenomedullin on gastric acid release using a new SRIF antagonist analogue
1 The effect of a new type 2 selective somatostatin (SRIF) receptor antagonist (DC‐41‐33) on somatostatin‐induced inhibition of pentagastrin‐stimulated gastric acid secretion in conscious, chronicExpand
  • 51
  • 6