D. Coy

Publications839
h-index80
Citations28,921
Highly Influential Citations497
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Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells.
TLDR
A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues and increased release of growth hormone, prolactin, corticotropin and luteinizing hormone from superfused rat pituitaries at as small a dose as 10(-10)M) or 10(-9)M (LH).
Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes.
TLDR
The highest concentration of radioimmunoassayable PACAP38 was found in the hypothalamus, but other brain regions also contained considerable amounts ofPACAP38, and the total amount of PACAP in both testes exceeded its content in the whole brain.
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
TLDR
Results indicate that SSTR5 is critical for physiologic regulation of GH and TSH, and SRIF analogs with selective affinity for this receptor may therefore be more effective in the treatment of hormone-secreting pituitary adenomas.
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
TLDR
The affinities of a battery of SRIF analogues to bind to SRIF receptor subtypes SSTR1 (cloned somatostatin complex), SSTR2, and SSTR3, as well as their abilities to inhibit the release of growth hormone from anterior pituitary cells in vitro are investigated.
Super-active analogs of growth hormone-releasing factor (1-29)-amide.
TLDR
Human pancreatic growth hormone releasing factor (1-29)-amide [hpGRF) and the following analogs were synthesized using solid phase methodology and tested for their ability to stimulate growth hormone (GH) secretion in the rat and the pig in vivo.
Localization and gene expression of the receptor for pituitary adenylate cyclase-activating polypeptide in the rat brain
TLDR
This study provides the basis for a better understanding of the functions of PACAP in the rat brain and raised antisera against a synthetic peptide that corresponds to the carboxy-terminal cytoplasmic domain which is found in all subtypes ofPACAPR.
The antimicrobial peptides and their potential clinical applications.
TLDR
To open the clinical applications, it is necessary and important to develop the synthetic and long-lasting AMP analogs that overcome the disadvantages of their natural peptides and the potential problems for the drug candidates.
Presence of highly selective receptors for PACAP (pituitary adenylate cyclase activating peptide) in membranes from the rat pancreatic acinar cell line AR 4‐2J
TLDR
This work characterized highly selective receptors for PACAP, the pituitary adenylate cyclase activating peptide, in the tumoral acinar cell line AR 4‐2J derived from the rat pancreas, and found their potency was much higher than that of VIP and helodemin.
RESPONSES TO ANALOGUES OF GROWTH HORMONE‐RELEASING HORMONE IN NORMAL SUBJECTS, AND IN GROWTH‐HORMONE DEFICIENT CHILDREN AND YOUNG ADULTS
TLDR
It is concluded that GHRH(1‐29)NH2 is a useful analogue in the testing of GH reserve in patients with growth hormone deficiency, and has considerable potential for long‐term therapy.
Examination of somatostatin involvement in the inhibitory action of GIP, GLP‐1, amylin and adrenomedullin on gastric acid release using a new SRIF antagonist analogue
TLDR
The results indicate that DC‐41‐33, is a potent in vivo inhibitor of exogenous and endogenous SRIF in rats, which represents a new class ofSRIF analogues which should eventually provide excellent tools for further evaluating the many physiological roles of SRIF and its five receptor subtypes.
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