S. Konturek

Publications828
h-index72
Citations23,920
Highly Influential Citations546
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Brain-gut axis and its role in the control of food intake.
Gastrointestinal tract (GIT) and nervous system, both central (CNS) and enteric (ENS), are involved in two-way extrinsic communication by parasympathetic and sympathetic nerves, each comprising… Expand
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Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options.
Stress, which is defined as an acute threat to homeostasis, shows both short- and long-term effects on the functions of the gastrointestinal tract. Exposure to stress results in alterations of the… Expand
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Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury.
BACKGROUND The exposure of gastric mucosa to damaging factors, such as ethanol, water restraint stress, or ischemia followed by reperfusion, produces pathological changes: inflammatory process,… Expand
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Neuro-hormonal control of food intake: basic mechanisms and clinical implications.
Obesity is one of the most common metabolic diseases and the greatest threats of the health because of possibility of numerous complications. In order to design effective drugs or apply the helpful… Expand
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Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome.
Metabolic syndrome (MS), defined as central obesity, hyperinsulinemia, insulin resistance, hypertension, dyslipidemia and glucose intolerance, has been associated with inflammatory biomarkers and… Expand
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Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT).
Melatonin (MT), an indole formed enzymatically from L-trytophan (Trp), was first discovered in the bovine pineal gland in 1958 by Lerner et al. Melatonin is the most versatile and ubiquitous hormonal… Expand
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Gut clock: implication of circadian rhythms in the gastrointestinal tract.
Circadian and seasonal rhythms are a fundamental feature of all living organisms and their organelles. Biological rhythms are responsible for daily food intake; the period of hunger and satiety is… Expand
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Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow.
BACKGROUND Endogenous nitric oxide has been implicated in the control of mesenteric circulation, but its role in the control of pancreatic blood flow and exocrine pancreatic secretion has not been… Expand
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Classic NSAID and selective cyclooxygenase (COX)‐1 and COX‐2 inhibitors in healing of chronic gastric ulcers
Prostaglandins (PG) derived from COX‐1 are essential for the maintenance of mucosal integrity but COX‐2 isoform synthesizes PG at a site of inflammation. Recently, COX‐2 mRNA expression was… Expand
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Role of prostaglandins in gastroprotection and gastric adaptation.
Since Robert discovery that pretreatment with prostaglandin (PG) applied in non-antisecretory dose can prevent the injury of gastric mucosa induced by necrotizing agents, much attention was paid to… Expand
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