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picropodophyllin

Known as: cyclolignan PPP, Picropodophyllotoxin, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))- 
A cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Glioblastoma (GB) is the most common malignant brain tumor in adults. It has limited treatment opportunities and is almost… Expand
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Highly Cited
2009
Highly Cited
2009
Insulin-like growth factor-I receptor (IGF-IR) is an important mediator of tumor cell survival and shows prognostic significance… Expand
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Highly Cited
2008
Highly Cited
2008
The insulin-like growth factor 1 receptor (IGF-1R) is crucial for growth and survival of malignant cells. Experience in targeting… Expand
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Highly Cited
2008
Highly Cited
2008
The protumorigenic insulin‐like growth factor (IGF)‐II is highly expressed in a significant fraction of human hepatocellular… Expand
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Highly Cited
2007
Highly Cited
2007
During the last decade, a central role for insulin‐like growth factor 1 (IGF‐1) in the pathophysiology of multiple myeloma (MM… Expand
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2006
2006
PURPOSE: Uveal melanoma has a high mortality rate due to a high incidence of metastasis (up to 50%), which preferentially occurs… Expand
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Highly Cited
2004
Highly Cited
2004
The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant… Expand
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Highly Cited
1984
Highly Cited
1984
Fourteen congeners of podophyllotoxin were evaluated for their abilities to induce DNA breakage and inhibit growth of A549 human… Expand
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Highly Cited
1982
Highly Cited
1982
The antiviral activity of an aqueous extract of Podophyllum peltatum was investigated. The extract was fractionated by reversed… Expand
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Highly Cited
1978
Highly Cited
1978
This study investigates the inhibition of microtubule assembly in vitro by podophyllotoxin and its derivatives, which include in… Expand
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