picropodophyllin

Known as: cyclolignan PPP, Picropodophyllotoxin, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))- 
A cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1… (More)
National Institutes of Health

Papers overview

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2010
2010
Glioblastoma (GB) is the most common malignant brain tumor in adults. It has limited treatment opportunities and is almost… (More)
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2010
2010
The insulin-like growth factor-1 receptor (Igf1r) is a multifunctional membrane-associated tyrosine kinase associated with… (More)
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2008
2008
The insulin-like growth factor 1 receptor (IGF-1R) is crucial for growth and survival of malignant cells. Experience in targeting… (More)
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2008
2008
PURPOSE The cyclolignan picropodophyllin (PPP) efficiently blocks the activity of insulinlike growth factor-1 receptor (IGF-1R… (More)
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2007
2007
During the last decade, a central role for insulin-like growth factor 1 (IGF-1) in the pathophysiology of multiple myeloma (MM… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Uveal melanoma has a high mortality rate due to a high incidence of metastasis (up to 50%), which preferentially occurs… (More)
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Highly Cited
2006
Highly Cited
2006
Insulin-like growth factor 1 (IGF-1) plays a pleiotropic role in multiple myeloma (MM), that is, in survival, proliferation… (More)
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Highly Cited
2004
Highly Cited
2004
The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant… (More)
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Highly Cited
1984
Highly Cited
1984
Fourteen congeners of podophyllotoxin were evaluated for their abilities to induce DNA breakage and inhibit growth of A549 human… (More)
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1978
1978
This study investigates the inhibition of microtubule assembly in vitro by podophyllotoxin and its derivatives, which include in… (More)
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