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picropodophyllin

Known as: cyclolignan PPP, Picropodophyllotoxin, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))- 
A cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (1)

AXL1717
NCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase Inhibitionanalogs & derivatives

Broader (1)

podofilox

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
miR-483-3p regulates acute myocardial infarction by transcriptionally repressing insulin growth factor 1 expression.
The aim of the present study was to evaluate the functional association between the expression of miR‑483‑3p and acute myocardial… 
2008
2008
New picropodophyllin analogs via palladium-catalyzed allylic alkylation-Hiyama cross-coupling sequences.
Unsaturated malonyl esters underwent Pd-catalyzed intramolecular allylic alkylation to give 4-vinyl-substituted gamma-lactones… 
Review
2007
Review
2007
Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I).
2005
2005
Apoptosis induced by one new podophyllotoxin glucoside in human carcinoma cells.
2005
2005
Cytotoxicity, apoptosis induction, and mitotic arrest by a novel podophyllotoxin glucoside, 4DPG, in tumor cells
AbstractAim:To define the in vitro cytotoxic activities of 4-demethyl-picropodophyllotoxin 7′-O-β-D-glucopyranoside (4DPG), a new… 
2002
2002
Hemi-synthesis and biological activity of new analogues of podophyllotoxin.
2001
2001
Two new podophyllotoxin glucosides from Sinopodophyllum emodi (Wall.) Ying.
Two new aryltetralin-type lignans, isopodophyllotoxin 7'-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (1) and 4… 
2000
2000
Synthesis and antineoplastic activity of cyclolignan aldehydes.
1985
1985
Comparative neurotoxicity of tubulin-binding drugs: inhibition of goldfish optic nerve regeneration.
Highly Cited
1975
Highly Cited
1975
Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein
Pharmacological evidence is presented for the involvement of microtubules in the process of fast axoplasmic transport. A… 
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