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Purpose Early phase I study of safety of AXL1717 in patients with recurrent or progressive malignant astrocytomas and evaluation… Expand Abstract Background: The primary objective of this study was to compare the progression-free survival (PFS) at 12 weeks between… Expand Background: The aim of the present study was to investigate any prognostic value of pre-treatment anemia, leukocytosis and… Expand Abstract
AXL1717 is an orally bioavailable IGF-1R pathway modulator that has been shown to have anti-tumoral effects. The… Expand 8091 Background: AXL1717 (picropodophyllin) is small molecule that inhibits the IGF-1R signaling pathway as well as suppresses… Expand The type 1 insulin-like growth factor receptor (IGF-1R) and its downstream signaling components have become increasingly… Expand Abstract Background. Inhibition of the Insulin-like Growth Factor-1 receptor (IGF-1R) has resulted in extensive anti-tumor… Expand A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determination of the new anticancer agent picropodophyllin… Expand Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL
The incidence of lung cancer has increased… Expand e13019 Background: Inhibition of the insulin-like growth factor-1 receptor (IGF-1R) has resulted in extensive antitumor effects… Expand