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podofilox

Known as: Podophyllinic acid lactone, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-, Podophyllotoxin 7 
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has… 
National Institutes of Health

Related topics

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46 relations

Narrower (29)

2-azapodophyllotoxin4'-demethyldesoxypodophyllotoxin4'-demethylepipodophyllic acid4'-demethylepipodophyllotoxin

Broader (2)

Antineoplastic Agents, PhytogenicKeratolytic Agents
CPH86EpipodophyllotoxinHypersensitivityIn Blood

Papers overview

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1990
1990
Occurrence of 5-methoxypodophyllotoxin in plants, cell cultures and regenerated plants of Linum flavum
The 5-methoxypodophyllotoxin contents of plants, cell cultures and regenerated plants of Linum flavum are compared. It is… 
1987
1987
Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.
The effects of microtubule inhibitors on cellular accumulation of 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidine-beta-D-glu… 
1986
1986
Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and alpha-peltatin analogues.
It has been reported that the action of etoposide (VP-16) (14) as an antitumor agent is mediated through its interaction with DNA… 
1985
1985
Genetic and biochemical studies with mutants of mammalian cells affected in microtubule-related proteins other than tubulin: mitochondrial localization of a microtubule-related protein.
In Chinese hamster ovary cells, stable mutants exhibiting specific resistance or collateral sensitivity towards the various… 
1981
1981
Penile condylomata acuminata: an experimental model for evaluation of topical self-treatment with 0.5--1.0% ethanolic preparations of podophyllotoxin for three days.
Penile condylomata were eradicated from 22 (54%) of 41 men whose lesions were painted twice (with a 72-hr interval) by the… 
1981
1981
Penile condylomata acuminata: an experimental model for evaluation of topical self-treatment with 0.5--1.0% ethanolic preparations of podophyllotoxin for three days.
Penile condylomata were eradicated from 22 (54%) of 41 men whose lesions were painted twice (with a 72-hr interval) by the… 
1978
1978
Structure, synthesis and orientation of microfibrils. V. On the recovery of Oocystis solitaria from microtubule inhibitor treatment.
Depending on the type of the inhibitor and its concentration one can experimentally induce two forms of aberrant microfibril… 
1977
1977
Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.
Summary The effects of various cytostatic agents (mechlorethamine, 1-β-d-arabinofuranosylcytosine, 6-mercaptopurine, methotrexate… 
1976
1976
Anion-induced increases in the rate of colchicine binding to tubulin.
The rate of binding of colchicine to tubulin to tubulin is enhanced by certain anions. Among the inorganic anions tested, only… 
Review
1970
Review
1970
Nineveh and Its Remains
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