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Epipodophyllotoxin

Known as: Epipodophyllotoxin Compound 
An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating… 
National Institutes of Health

Related topics

Related topics

4 relations
EtoposideVP 16-213Vepesidpodofilox

Papers overview

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Highly Cited
1989
Highly Cited
1989
DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells.
This study demonstrated that agents capable of interacting with the minor groove in nuclear DNA interfere with topoisomerase II… 
Review
1989
Review
1989
Etoposide in leukemia, lymphoma and bone marrow transplantation.
Highly Cited
1986
Highly Cited
1986
Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.
Recent evidence indicates that type II DNA topoisomerases mediate epipodophyllotoxin-induced DNA damage and may be intrinsic to… 
Highly Cited
1986
Highly Cited
1986
Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target.
Several intercalating agents, as well as the epipodophyllotoxins, appear to effect DNA damage through their interaction with type… 
Highly Cited
1982
Highly Cited
1982
Prophylactic chemotherapy of superficial transitional cell bladder carcinoma: an EORTC randomized trial comparing thiotepa, an epipodophyllotoxin (VM26) and TUR alone.
The Urological Group of the European Organization for Research on Treatment of Cancer (EORTC) has performed a randomized clinical… 
1977
1977
Comparative study of early effects of epipodophyllotoxin derivatives and other cytostatic agents on mastocytoma cultures.
Summary The effects of various cytostatic agents (mechlorethamine, 1-β-d-arabinofuranosylcytosine, 6-mercaptopurine, methotrexate… 
Highly Cited
1976
Highly Cited
1976
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Highly Cited
1975
Highly Cited
1975
Comparison of the human pharmacokinetics of VM-26 and VP-16, two antineoplastic epipodophyllotixin glucopyranoside derivatives.
Highly Cited
1975
Highly Cited
1975
EPEG, a new antineoplastic epipodophyllotoxin
Nine patients were studied with tritium‐labeled EPEG, a new epipodophyllotoxin antineoplastic agent. Four patients received 220… 
Highly Cited
1975
Highly Cited
1975
Inhibition by 4'-demethyl-epipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) of human lymphoblast cultures in G2 phase of the cell cycle.
4'-Demethyl-epipodophyllotoxin 9-(4,6-0-2-thenylidene-beta-D-glucopyranoside) is a semisynthetic derivative of podophyllotoxin… 
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