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Siglecs and their roles in the immune system
The postulated functions of the recently discovered CD33-related Siglecs are discussed and the factors that seem to be driving their rapid evolution are considered.
New World Bats Harbor Diverse Influenza A Viruses
Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
The hemagglutinin structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA, which suggests a path for this H 5N1 virus to gain a foothold in the human population.
Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
A structural basis for the hypothesis that pigs may serve as “mixing vessels” for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics is demonstrated.
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.
- O. Blixt, Steve Head, J. Paulson
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 7 December 2004
A glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins.
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
The data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface.
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.
Siglec-mediated regulation of immune cell function in disease
The recent advances in understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer are described.
Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin.
Symbol Nomenclature for Graphical Representations of Glycans.
Author(s): Varki, Ajit; Cummings, Richard D; Aebi, Markus; Packer, Nicole H; Seeberger, Peter H; Esko, Jeffrey D; Stanley, Pamela; Hart, Gerald; Darvill, Alan; Kinoshita, Taroh; Prestegard, James J;…