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GSK-3-selective inhibitors derived from Tyrian purple indirubins.
TLDR
6-bromoindirubins provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3, and closely mimicked Wnt signaling in Xenopus embryos. Expand
The Malassezia Genus in Skin and Systemic Diseases
TLDR
Seven new taxa isolated from healthy and lesional human and animal skin have been accepted and metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia-synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis. Expand
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
TLDR
Using the cocrystal structures of various indirubins with GSK-3beta, CDK2 and CDK5/p25, this modeling approach provided some insight into the molecular basis of indirUBins' action and selectivity and allowed some improvements of this family of bis-indoles as kinase inhibitors to be forecast. Expand
The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits.
TLDR
Oleuropein, for 3 or 6 wk, reduced the infarct size, conferred strong antioxidant protection and reduced the circulating lipids, and this is the first experimental study in vivo that suggests the possibility of using an olive constituent in the treatment of ischemia. Expand
Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
TLDR
The content of polyphenols in table olives is highly influenced by the olive variety and the debittering process applied on the fruits, so an approximate quantity of 25 mg of oleuropein per day can be considered as safe for human use, since it can be found in the usual diet. Expand
In Vitro and In Vivo Activities of Chios Mastic Gum Extracts and Constituents against Helicobacter pylori
TLDR
Results show that administration of TMEWP may be effective in reducing H. pylori colonization and that the major triterpenic acids in the acid extract may be responsible for such an activity. Expand
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
TLDR
The new derivatives with an extended amino side chain attached at position 3' showed potent GSK-3 inhibitory activity, enhanced selectivity, and dramatically increased water solubility, suggesting that they might constitute tools to investigate circadian rhythm regulation. Expand
A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
TLDR
A pilot scale system for the treatment of the olive oil mills wastewater was developed aiming at the recovery of high added value-contained polyphenols and the reduction of the environmental problems. Expand
1H NMR-based metabonomics for the classification of Greek wines according to variety, region, and vintage. Comparison with HPLC data.
A sensitive and simple method was developed for the classification of wines according to variety, geographical origin, and vintage using NMR-based metabonomics. Polyphenol-rich extracts were preparedExpand
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins
TLDR
Results suggest that AhR activation, rather than kinase inhibition, is responsible for the cytostatic effects of some indirubins, and represents the main mechanism underlying the cytotoxic properties of this class of promising antitumor molecules. Expand
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