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phospholipase A2-alpha

Known as: cPLA2-Alpha, Phospholipases, cPLA2, PLA2G4A 
Cytosolic phospholipase A2 (749 aa, ~85 kDa) is encoded by the human PLA2G4A gene. This protein is involved in arachidonic acid metabolism.
National Institutes of Health

Related topics

Related topics

30 relations
Arachidonic Acid Metabolism PathwayC2 DomainsCytosolic Phospholipase A2Enzyme Gene
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Broader (2)

LysophospholipasePhospholipases A2

Papers overview

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Review
2015
Review
2015
Cytosolic phospholipase A2: physiological function and role in disease
The group IV phospholipase A2 (PLA2) family is comprised of six intracellular enzymes (GIVA, -B, -C, -D, -E, and -F) commonly… Expand
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Review
2006
Review
2006
Properties of the Group IV phospholipase A2 family.
The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly called cytosolic phospholipase A2 (cPLA2… Expand
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Review
2006
Review
2006
Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia.
Ischemic stroke is caused by obstruction of blood flow to the brain, resulting in energy failure that initiates a complex series… Expand
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Highly Cited
2003
Highly Cited
2003
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.
The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and… Expand
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Review
2002
Review
2002
Phospholipase A2 enzymes.
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic… Expand
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Highly Cited
1998
Highly Cited
1998
Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom.
BACKGROUND Specific immunotherapy with honeybee venom (BV) is highly effective, but allergic side effects can occur during… Expand
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Highly Cited
1997
Highly Cited
1997
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2
Phospholipase A2 (PLA2) enzymes are critical regulators of prostaglandin and leukotriene synthesis and can directly modify the… Expand
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Highly Cited
1997
Highly Cited
1997
Role of cytosolic phospholipase A2 in allergic response and parturition
Phospholipase A2 (PLA2) comprises a superfamily of enzymes that hydrolyse the ester bond of phospholipids at the sn-2 position… Expand
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Review
1995
Review
1995
Cytosolic phospholipase A2.
To summarize the regulation of cPLA2, we have proposed a model for the activation of cPLA2 based both on our previous studies… Expand
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Highly Cited
1995
Highly Cited
1995
Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
Nonpancreatic secretory phospholipase A2 (sPLA2) displays proinflammatory properties; however, its physiological substrate is not… Expand
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