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phospholipase A2-alpha

Known as: cPLA2-Alpha, Phospholipases, cPLA2, PLA2G4A 
Cytosolic phospholipase A2 (749 aa, ~85 kDa) is encoded by the human PLA2G4A gene. This protein is involved in arachidonic acid metabolism.
National Institutes of Health

Papers overview

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Review
2015
Review
2015
The group IV phospholipase A2 (PLA2) family is comprised of six intracellular enzymes (GIVA, -B, -C, -D, -E, and -F) commonly… Expand
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Review
2006
Review
2006
The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly called cytosolic phospholipase A2 (cPLA2… Expand
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Review
2006
Review
2006
Ischemic stroke is caused by obstruction of blood flow to the brain, resulting in energy failure that initiates a complex series… Expand
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Highly Cited
2003
Highly Cited
2003
The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and… Expand
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Review
2002
Review
2002
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Specific immunotherapy with honeybee venom (BV) is highly effective, but allergic side effects can occur during… Expand
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Highly Cited
1997
Highly Cited
1997
Phospholipase A2 (PLA2) enzymes are critical regulators of prostaglandin and leukotriene synthesis and can directly modify the… Expand
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Highly Cited
1997
Highly Cited
1997
Phospholipase A2 (PLA2) comprises a superfamily of enzymes that hydrolyse the ester bond of phospholipids at the sn-2 position… Expand
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Review
1995
Review
1995
To summarize the regulation of cPLA2, we have proposed a model for the activation of cPLA2 based both on our previous studies… Expand
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Highly Cited
1995
Highly Cited
1995
Nonpancreatic secretory phospholipase A2 (sPLA2) displays proinflammatory properties; however, its physiological substrate is not… Expand
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