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phospholipase A2-alpha
Known as:
cPLA2-Alpha
, Phospholipases, cPLA2
, PLA2G4A
Â
(More)
Cytosolic phospholipase A2 (749 aa, ~85 kDa) is encoded by the human PLA2G4A gene. This protein is involved in arachidonic acid metabolism.
National Institutes of Health
Topic mentions per year
Topic mentions per year
1949-2018
0
20
40
1949
2017
Related topics
Related topics
33 relations
Arachidonic Acid Metabolism Pathway
C2 Domains
Cytosolic Phospholipase A2
Enzyme Gene
(More)
Broader (2)
Lysophospholipase
Phospholipases A2
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
phospholipase A2-alpha
Hydrolysis
Signal Transduction
inflammatory response
physiological aspects
Hydrolase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
Elion Hoxha
,
Ina Thiele
,
Gunther Zahner
,
Ulf Panzer
,
Sigrid Harendza
,
Rolf A K Stahl
Journal of the American Society of Nephrology…
2014
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, with an uncertain clinical outcome. The…Â
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2010
2010
Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.
Kuan-Pin Su
,
Shih-Yi Huang
,
+5 authors
Carmine M Pariante
Biological psychiatry
2010
BACKGROUND Phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2) are the two key enzymes in the metabolism of polyunsaturated fatty…Â
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2008
2008
Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer.
Manish I Patel
,
Jaskirat Singh
,
+10 authors
Qihan Dong
Clinical cancer research : an official journal of…
2008
PURPOSE Cytosolic phospholipase A2-alpha (cPLA2-alpha) provides intracellular arachidonic acid to supply both cyclooxygenase and…Â
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2007
2007
The confluence-dependent interaction of cytosolic phospholipase A2-alpha with annexin A1 regulates endothelial cell prostaglandin E2 generation.
Shane P. Herbert
,
Adam F Odell
,
Sreenivasan Ponnambalam
,
John H. Walker
The Journal of biological chemistry
2007
The regulated generation of prostaglandins from endothelial cells is critical to vascular function. Here we identify a novel…Â
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Highly Cited
1997
Highly Cited
1997
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.
Joseph V. Bonventre
,
Z. Huang
,
+4 authors
Adam Sapirstein
Nature
1997
Phospholipase A2 (PLA2) enzymes are critical regulators of prostaglandin and leukotriene synthesis and can directly modify the…Â
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Highly Cited
1997
Highly Cited
1997
Role of cytosolic phospholipase A2 in allergic response and parturition.
Naofumi Uozumi
,
K. Kume
,
+9 authors
T. Shimizu
Nature
1997
Phospholipase A2 (PLA2) comprises a superfamily of enzymes that hydrolyse the ester bond of phospholipids at the sn-2 position…Â
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Highly Cited
1996
Highly Cited
1996
Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain.
D. T. Stephenson
,
Cynthia A Lemere
,
D. J. Selkoe
,
Jeffrey Clemens
Neurobiology of disease
1996
Phospholipase A2 (PLA2) is the key enzyme that initiates the arachidonic acid cascade, which leads to the generation of multiple…Â
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Highly Cited
1992
Highly Cited
1992
Surface structure and properties of plant seed oil bodies
Jason Tze-Cheng Tzen
,
A. H. - L. Huang
The Journal of cell biology
1992
Storage triacylglycerols (TAG) in plant seeds are present in small discrete intracellular organelles called oil bodies. An oil…Â
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Highly Cited
1980
Highly Cited
1980
A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.
Fusao Hirata
,
Elliot Schiffmann
,
Krishna K. Venkatasubramanian
,
Daniel R. Salomon
,
J. D. Axelrod
Proceedings of the National Academy of Sciences…
1980
When rabbit peritoneal neutrophils were treated with glucocorticoids, their chemotactic response to stimulation by the…Â
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1977
1977
Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants.
Robert L Heinrikson
,
Eckard Krueger
,
Paul S Keim
The Journal of biological chemistry
1977
The complete amino acid sequence of Crotalus adamanteus venom phospholipase A2-alpha has been determined by analysis of the five…Â
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