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phospholipase A2-alpha

Known as: cPLA2-Alpha, Phospholipases, cPLA2, PLA2G4A 
Cytosolic phospholipase A2 (749 aa, ~85 kDa) is encoded by the human PLA2G4A gene. This protein is involved in arachidonic acid metabolism.
National Institutes of Health

Related topics

Related topics

30 relations
Arachidonic Acid Metabolism PathwayC2 DomainsCytosolic Phospholipase A2Enzyme Gene

Broader (2)

LysophospholipasePhospholipases A2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c‐fos through ERK‐dependent and independent pathways in mast cells
Cytosolic phospholipase A2 (cPLA2) is a Ca2+‐dependent enzyme that mediates agonist‐dependent arachidonic acid release in most… 
Highly Cited
1998
Highly Cited
1998
Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2.
The amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) mediates an initial step in the production… 
Highly Cited
1996
Highly Cited
1996
Purification and Properties of a Cytosolic V1-ATPase*
The native V1 complex of the tobacco hornworm vacuolar type ATPase (V-ATPase) was purified from cytosolic extracts of molting… 
Highly Cited
1995
Highly Cited
1995
Activation of intracellular proteases is an early event in TNF-induced apoptosis.
The serine protease inhibitor tosyl-argenine methyl ester inhibits TNF-induced apoptosis, suggesting that proteolysis is… 
Highly Cited
1995
Highly Cited
1995
Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells.
Highly Cited
1995
Highly Cited
1995
Type I skin reactivity to native and recombinant phospholipase A2 from honeybee venom is similar.
Highly Cited
1993
Highly Cited
1993
Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene
As part of an investigation into the effects of endogenous retroviruses on adjacent genes, we have isolated a cDNA clone derived… 
Highly Cited
1990
Highly Cited
1990
Purification of a phospholipase A2 from human monocytic leukemic U937 cells. Calcium-dependent activation and membrane association.
Highly Cited
1986
Highly Cited
1986
Platelet activation—a role for a 40K anti-phospholipase A2 protein indistinguishable from lipocortin
Stimulus–response (S–R) coupling in platelets requires an intermediary other than an elevation in cytosolic free calcium ([Ca2+]i… 
Highly Cited
1974
Highly Cited
1974
The amino-acid sequence and carbohydrate content of phospholipase A2 from bee venom.
The complete amino acid sequence of phospholipase A2 from the venom of the common European honey-bee (Apis mellifica) has been… 
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