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Cytosolic Phospholipase A2

Known as: PLA(2)-IV, Phospholipase A2G4, Phospholipase A2IV 
A cytosolic phospholipase A2 group that plays an important role in the release of free ARACHIDONIC ACID, which in turn is metabolized to… 
National Institutes of Health

Related topics

Related topics

23 relations
C2 DomainsHydrolysisIn BloodLipid Metabolism

Narrower (6)

Group IVA Phospholipase A2Group IVE Phospholipase A2Group IVF Phospholipase A2PLA2G4A protein, human

Papers overview

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Highly Cited
2015
Highly Cited
2015
Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway
BackgroundOxidative stress and inflammation are important factors contributing to the pathophysiology of numerous neurological… 
Highly Cited
2006
Highly Cited
2006
Regulation of Cytosolic Phospholipase A2 Activation and Cyclooxygenase 2 Expression in Macrophages by the β-Glucan Receptor*
Phagocytosis of non-opsonized microorganisms by macrophages initiates innate immune responses for host defense against infection… 
Highly Cited
2005
Highly Cited
2005
Toll-like Receptor 4 Signaling Regulates Cytosolic Phospholipase A2 Activation and Lipid Generation in Lipopolysaccharide-stimulated Macrophages*
Inflammatory lipid mediators such as prostaglandins and leukotrienes play crucial roles in the pathogenesis of bacterial… 
Highly Cited
1998
Highly Cited
1998
Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies.
Lipid bodies are inducible lipid domains abundantly present in leukocytes engaged in inflammation. They are rich in esterified… 
Highly Cited
1997
Highly Cited
1997
Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer*
Mutations in Ras family members that confer oncogenic potential are frequently observed in specific human cancers. We report that… 
Highly Cited
1996
Highly Cited
1996
Shear stress activates cytosolic phospholipase A2 (cPLA2) and MAP kinase in human endothelial cells.
Intracellular signalling events that govern endothelial responses to shear are incompletely defined. In this study confluent… 
Highly Cited
1996
Highly Cited
1996
Ras Activation Is Necessary for Integrin-mediated Activation of Extracellular Signal-regulated Kinase 2 and Cytosolic Phospholipase A2 but Not for Cytoskeletal Organization*
Cell adhesion to the extracellular matrix triggers a cascade of intracellular biochemical signals regulated by the integrin… 
Highly Cited
1996
Highly Cited
1996
Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.
BACKGROUND AND PURPOSE Phospholipid breakdown has been reported to be an early event in the brain after global cerebral ischemia… 
Highly Cited
1996
Highly Cited
1996
Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis.
Cytosolic phospholipase A2 (cPLA2) is a good candidate for mediating the agonist-stimulated release of arachidonic acid (AA) from… 
Highly Cited
1990
Highly Cited
1990
Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.
The major dithiothreitol-resistant phospholipase A2 activity present in the cytosol of U937 cells has been purified greater than… 
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