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Erratum to: Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
TLDR
Analysis of the mtDNA haplogroups, which are shared between Indian and Iranian populations and exhibit coalescence ages corresponding to around the early Upper Paleolithic, indicates that they are present in India largely as Indian-specific sub-lineages. Expand
Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
TLDR
This work uses recently released sequences from the 1000 Genomes Project to identify two western African-specific missense mutations in the neighboring APOL1 gene, and demonstrates that these are more strongly associated with ESKD than previously reported MYH9 variants. Expand
The genome-wide structure of the Jewish people
TLDR
High-density bead arrays to genotype individuals from 14 Jewish Diaspora communities are used to compare patterns of genome-wide diversity with those from 69 Old World non-Jewish populations, of which 25 have not previously been reported. Expand
The Genetic Legacy of Religious Diversity and Intolerance: Paternal Lineages of Christians, Jews, and Muslims in the Iberian Peninsula
TLDR
Analysis of haplotype sharing and diversity within specific haplogroups suggests that the Sephardic Jewish component is the more ancient, and the geographical distribution of North African ancestry in the peninsula does not reflect the initial colonization and subsequent withdrawal and is likely to result from later enforced population movement plus the effects of genetic drift. Expand
Insulin production by human embryonic stem cells.
TLDR
Sp spontaneous in vitro differentiation that included the generation of cells with characteristics of insulin-producing beta-cells is observed, validating the hES cell model system as a potential basis for enrichment of human beta- cells or their precursors, as a possible future source for cell replacement therapy in diabetes. Expand
Y chromosomes traveling south: the cohen modal haplotype and the origins of the Lemba--the "Black Jews of Southern Africa".
TLDR
The high resolution afforded by the markers shows that Lemba Y chromosomes are clearly divided into Semitic and Bantu clades, and one of the Lemba clans carries a particular Y-chromosome type termed the "Cohen modal haplotype," which is thought to be a potential signature haplotype of Judaic origin. Expand
Counting the Founders: The Matrilineal Genetic Ancestry of the Jewish Diaspora
TLDR
The numerically major portion of the non-Ashkenazi Jews, currently estimated at 5 million people and comprised of the Moroccan, Iraqi, Iranian and Iberian Exile Jewish communities showed no evidence for a narrow founder effect, which did however characterize the smaller and more remote Belmonte, Indian and the two Caucasus communities. Expand
Multiple origins of Ashkenazi Levites: Y chromosome evidence for both Near Eastern and European ancestries.
TLDR
Comparisons with other Jewish and non-Jewish groups suggest that a founding event, probably involving one or very few European men occurring at a time close to the initial formation and settlement of the Ashkenazi community, is the most likely explanation for the presence of this distinctive haplogroup found today in >50% ofAshkenazi Levites. Expand
Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions.
TLDR
It is shown that, in addition to several satellite and non-satellite repeats, the subtelomeric regions in lymphoblastoid and fibroblast cells of ICF patients are also hypomethylated to similar levels as in sperm. Expand
Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
TLDR
Results indicate that Sirt1 overexpression in proximal tubules rescues cisplatin-induced AKI by maintaining peroxisomes number and function, concomitant up-regulation of catalase, and elimination of renal ROS levels. Expand
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