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Prevalence and Quantitation of Species C Adenovirus DNA in Human Mucosal Lymphocytes
TLDR
The frequent finding of significant quantities of adenovirus DNA in tonsil and adenoid tissues, infectious virus was rarely present, as measured by coculture with permissive cells. Expand
Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.
TLDR
Time-lapse video microscopy is used to observe the death of several TNF-sensitive target cell lines while measuring the release of Na2(51)CrO4 and [3H]TdR from cytoplasmic and nuclear compartments, respectively, and finds that the type of cell death observed depends on the cell being tested. Expand
Latent Species C Adenoviruses in Human Tonsil Tissues
TLDR
The data suggest that species C adenoviruses can establish latent infections in mucosal lymphocytes and that stimulation of these cells can cause viral reactivation resulting in RNA transcription, DNA replication, and infectious virus production. Expand
Three Adenovirus E3 Proteins Cooperate to Evade Apoptosis by Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor-1 and -2*
TLDR
A mechanism for viral modulation of TRAIL receptor-mediated apoptosis is identified and it is suggested that the E3 protein complex has evolved to regulate the signaling of selected cytokine receptors. Expand
A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact
TLDR
It is found that an uncleavable mutant of the 26 kd cell surface transmembrane form of TNF kills tumor cells and virus-infected cells by cell-to-cell contact, and that TNF need not be internalized by its target to kill. Expand
The adenovirus E3-10.4K/14.5K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis.
TLDR
It is shown that, as an early event during infection, the adenovirus E3-10.4K/14.5K complex selectively induces loss of Fas surface expression and blocks Fas-induced apoptosis of virus-infected cells, suggesting yet another mechanism by which adanovirus modulates host cytotoxic responses that may contribute to persistent infection by humanAdenoviruses. Expand
A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor
TLDR
The results support the hypothesis that one of the functions of TNF in vivo is to combat virus infections, and that the 14,700 MW protein evolved in adenovirus to counteract the antiviral effects of T NF. Expand
T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.
TLDR
This work analyzed how a tissue-specific protein with defined timing and location of expression is recognized by T cells so as to induce tolerance or autoimmunity and argued that T cells may become spontaneously autoreactive to certain postnatally expressed peripheral proteins and that this reactivity may lead to autoimmune disease. Expand
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.
TLDR
All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution. Expand
The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.
TLDR
It is proposed that by suppressing an intrinsic cell death mechanism activated by TNF-alpha or E1A, the E1B 19K protein enhances the transforming activity of E 1A and enables adenovirus to evade T NF-alpha-dependent immune surveillance. Expand
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