Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Store-operated calcium channels.
In electrically nonexcitable cells, Ca(2+) influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and… Expand
Store depletion and calcium influx.
Calcium influx in nonexcitable cells regulates such diverse processes as exocytosis, contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant Ca2+ entry pathway… Expand
Store-operated CRAC channels: function in health and disease
- A. Parekh
- Biology, Medicine
- Nature Reviews Drug Discovery
- 1 May 2010
Elevation of cytosolic Ca2+ levels through the activation of store-operated Ca2+ release-activated Ca2+ (CRAC) channels is involved in mediating a disparate array of cellular responses. These include… Expand
Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane.
- A. Parekh
- Biology, Chemistry
- The Journal of physiology
- 1 March 2003
In eukaryotic cells, hormones and neurotransmitters that engage the phosphoinositide pathway evoke a biphasic increase in intracellular free Ca2+ concentration: an initial transient release of Ca2+… Expand
Respiring mitochondria determine the pattern of activation and inactivation of the store‐operated Ca2+ current ICRAC
- J. Gilabert, A. Parekh
- Biology, Medicine
- The EMBO journal
- 1 December 2000
In eukaryotic cells, hormones and neurotransmitters that engage the phosphoinositide pathway evoke a biphasic increase in intracellular free Ca2+ concentration: an initial transient release of Ca2+… Expand
The Store-Operated Calcium Current ICRAC: Nonlinear Activation by InsP3 and Dissociation from Calcium Release
Patch-clamp experiments aimed at determining the relationship between intracellular Ca2+ release and activation of store-operated calcium current I(CRAC) reveal that both agonist and InsP3-mediated… Expand
Decoding cytosolic Ca2+ oscillations.
- A. Parekh
- Biology, Medicine
- Trends in biochemical sciences
- 1 February 2011
A rise in cytosolic Ca(2+) concentration is used as a universal signalling mechanism to control biological processes as diverse as exocytosis, contraction, cell growth and cell death. Ca(2+) signals… Expand
Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+ Release-activated Ca2+ (CRAC) Channels*
NFATs are a family of Ca2+-dependent transcription factors that play a central role in the morphogenesis, development, and physiological activities of numerous distinct cell types and organ systems.… Expand
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.
Whole-cell patch-clamp recordings and single-cell Ca2+ measurements were used to study the control of Ca2+ entry through the Ca2+ release-activated Ca2+ influx pathway (ICRAC) in rat basophilic… Expand
Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx
- J. Gilabert, D. Bakowski, A. Parekh
- Biology, Medicine
- The EMBO journal
- 1 June 2001
In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide pathway evokes a biphasic increase in intracellular free Ca2+ concentration: an initial transient phase… Expand