pepstatin

Known as: Ahpatinin C, Pepsin inhibitor S 735A, N-Isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-gamma-aminoheptanoyl-L-alanyl-3-hydroxy-6-methyl-gamma-aminoheptanoic Acid 
 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
In the United States, more than 40% of cancer patients develop brain metastasis. The median survival for untreated patients is 1… (More)
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Highly Cited
2003
Highly Cited
2003
AbstractThere is increasing evidence that proteases other than caspases, for example, the lysosomal cathepsins B, D and L, are… (More)
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Highly Cited
2001
Highly Cited
2001
It has been suggested that lysosomes and the lysosomal proteases cathepsin D and B act as proapoptotic mediators of apoptosis, in… (More)
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Highly Cited
2001
Highly Cited
2001
We propose a new mechanism for sphingosine-induced apoptosis, involving relocation of lysosomal hydrolases to the cytosol. Owing… (More)
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Highly Cited
1997
Highly Cited
1997
Vascular endothelial growth factor (VEGF) is an angiogenic polypeptide that has been implicated in cancer growth. In the present… (More)
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Highly Cited
1991
Highly Cited
1991
Oxygen free radicals and oxidative events have been implicated as playing a role in bringing about the changes in cellular… (More)
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Highly Cited
1990
Highly Cited
1990
Incubation of intact rat fat cells with maximally effective concentrations of insulin (1 nM, 12 min) or isoprenaline (300 nM, 3… (More)
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Highly Cited
1988
Highly Cited
1988
We previously reported that in childhood adrenoleukodystrophy (C-ALD) and adrenomyeloneuropathy (AMN), the peroxisomal beta… (More)
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Highly Cited
1988
Highly Cited
1988
It has been proposed that proteases secreted by cancer cells facilitate metastasis by degrading extracellular matrix. Estrogen… (More)
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1976
1976
Four derivatives of pepstatin, each of which contains the unusual amino acid 4-amino-3-hydroxy-6-methylheptanoic acid (statine… (More)
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