Inhibition of the Renin-Angiotensinogen Reaction by Pepstatin

@article{Gross1972InhibitionOT,
  title={Inhibition of the Renin-Angiotensinogen Reaction by Pepstatin},
  author={Franz Gross and J. Lazar and H. Orth},
  journal={Science},
  year={1972},
  volume={175},
  pages={656 - 656}
}
Pepstatin, an N-acylated pentapeptide obtained from culture filtrates of actinomycetes and first characterized as an inhibitor of pepsin, produces inhibition of the renin-substrate reaction both in vitro and in vivo. 
Inhibition of human plasma renin activity by pepstatin.
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Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D.
  • J. Woessner
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • 1972
Abstract Pepstatin, a peptide inhibitor of pepsin isolated from cultures of Actinomycetes, is shown to be a powerful inhibitor of cathepsin D preparations obtained from bovine uterus and rabbit earExpand
Effect of several proteinase inhibitors on renin reaction.
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Inhibitory effect of the following nine proteinase inhibitors on the renin activity was studied: Trasylol, pepstatin A, chymostatin, antipain and leupeptin, which inhibited renin in vitro. Expand
One-step separation of human plasma angiotensinogen from renin.
TLDR
Human plasma angiotensinogen was totally separated from renin by chromatography on a Sepharose-hexamethylenediamine-Pepstatin column and 95% of the enzyme was recovered with a 25-fold purification. Expand
Kinetics of the Inhibitory Effect of Pepstatin on the Reaction of Hog Renin with Rat Plasma Substrate
TLDR
The reaction between hog renin and rat angiotensinogen followed Michaelis-Menten kinetics and pepstatin inhibited the reaction in a noncompetitive way, since renin activity could be restored by 24 hours of dialysis against distilled water. Expand
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References

SHOWING 1-6 OF 6 REFERENCES
A micromethod for measurement of renin in the plasma and kidney of rats.
TLDR
A new micromethod for the measurement of renin activity and substrate in 0.1 ml of rat plasma and 1 mg of rat renal tissue is described, which permits repeated measurements of renIn activity in rats during acute experiments and in any physiological procedure. Expand
0. Carretero and F. Gross, Naunyn-Schnledebergs Arch
  • Recent Progr. Hormone Res
  • 1965
RENIN-ANGIOTENSIN SYSTEM, ALDOSTERONE, AND SODIUM BALANCE.
We thank Professor H. Umezawa for the pepstatin and H. Malorny and U. Miksche for technical assistance