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Pepstatins

Known as: Pepstatins [Chemical/Ingredient] 
N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid proteases such as pepsin and renin.
National Institutes of Health

Related topics

Related topics

20 relations
In BloodProcess of secretionagonistsantagonists & inhibitors

Narrower (11)

JMV4463N-pepstatinyl-N'-dansyldiaminopropaneStreptomyces pepsin inhibitorhydroxypepstatin

Broader (1)

Protease Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Simplified pepstatins: synthesis and evaluation of N-terminally modified analogues.
The promising strategy of gastric ulcer healing with perorally administered epidermal growth factor (EGF) is so far strongly… 
Review
1993
Review
1993
Pepstatins: Aspartic proteinase inhibitors having potential therapeutic applications
1983
1983
Dinitrophenyl-pepstatins as active-site-directed localization reagents for cathepsin D.
1. N-Pepstatinyl-N'-dinitrophenyl-1,6-diaminohexane, a potential active-site-directed localization reagent for cathepsin D, was… 
1982
1982
The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D.
Lactoyl-pepstatin (an acylated tetrapeptide) is much more readily soluble in aqueous media than the more common isovaleryl- and… 
1978
1978
Soluble pepstatins: a new approach to blockade in vivo of the renin-angiotensin system.
1. Synthesis of several pepstatin A derivatives was performed with the aim of increasing water solubility without altering the… 
1975
1975
N-acylated derivatives of a peptide obtained by enzymatic degradation of pepstatins.
Sir: Naturally occurring pepstatins have been shown to possess two moles of an interesting amino acid, 4-amino-3-hydroxy-6… 
1975
1975
Enzymatic degradation of pepstatin A to a new tetrapeptide.
general structural formula can be shown as follows: R-L-valyl-L-valyl-4-amino-3-hydroxy6-methylheptanoyl-L-alanyl-4-amino3… 
1973
1973
Letter: New pepstatins, pepstatins Bu, Pr and Ac produced by Streptomyces.
Highly Cited
1972
Highly Cited
1972
Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin.
The inhibition of pepsin, cathepsin D and renin by pepstatins, pepstanone A and their partial peptides is described. A new method… 
1972
1972
New pepstatins, pepstatins B and C, and pepstanone A, produced by streptomyces.
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