Pepstatins

Known as: Pepstatins [Chemical/Ingredient]

N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid proteases such as pepsin and renin.

National Institutes of Health

Papers overview

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1983

1. N-Pepstatinyl-N'-dinitrophenyl-1,6-diaminohexane, a potential active-site-directed localization reagent for cathepsin D, was…

1982

Lactoyl-pepstatin (an acylated tetrapeptide) is much more readily soluble in aqueous media than the more common isovaleryl- and…

1982

The therapeutic value of pepstatins, which are inhibitors of acid proteinases isolated from Streptomyce% is lessened by their…

1980

Extracellular cathepsin D has been observed by various cytochemical methods at sites of tissue injury. However, the role of this…

1979

A series of peptides having a valine or valyvaline moiety at the N-terminus, 1-13, was prepared and their antipepsin activities…

1975

Sir: Naturally occurring pepstatins have been shown to possess two moles of an interesting amino acid, 4-amino-3-hydroxy-6…

1975

general structural formula can be shown as follows: R-L-valyl-L-valyl-4-amino-3-hydroxy6-methylheptanoyl-L-alanyl-4-amino3…