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Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya.
19F NMR has provided evidence that the organism synthesizes fluoroacetate under the same fermentation conditions and the in vitro antibacterial spectrum of 4-fluorothreonine is presented. Expand
Proflamin, a new antitumor agent: preparation, physicochemical properties and antitumor activity.
The antitumor effect of proflamin was studied with murine tumors and produced no lethal or any other apparent adverse effect in mice, and exhibited no cytocidal effect against the cultured cell lines in vitro. Expand
Structural study of a new antitumor antibiotic, kazusamycin.
The structure of a new antitumor antibiotic produced by Streptomyces sp. Expand
A new antitumor antibiotic, kazusamycin.
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possessExpand
beta-Ethynylserine, an antimetabolite of L-threonine, from Streptomyces cattleya.
A new antitumor antibiotic, awamycin.
A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and hasExpand
Structure of awamycin, a novel antitumor ansamycin antibiotic.