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Conformational Dependence of Collagenase (Matrix Metalloproteinase-1) Up-regulation by Elastin Peptides in Cultured Fibroblasts*
Results of the biophysical studies suggest that this peculiar consensus sequence stabilizes a type VIII β-turn in several similar, but not identical, peptides that maintain a sufficient conformation to be recognized by the elastin receptor. Expand
Elastin-elastases and inflamm-aging.
The myriad of biological effects exerted by elastokines on stromal and inflammatory cells led us to hypothesize that they might be main actors in elaborating a favorable cancerization field in melanoma; for instance these peptides could catalyze the vertical growth phase transition in melanomas through increased expression of gelatinase A and membrane-type 1 matrix metalloproteinase. Expand
The Elastin Receptor Complex Transduces Signals through the Catalytic Activity of Its Neu-1 Subunit*
It is shown that the elastin peptide-driven ERK1/2 activation and subsequent pro-MMP-1 production, observed in skin fibroblasts when they are cultured in the presence of these peptides, rely on a membrane-bound sialidase activity. Expand
Growth stimulation of human keratinocytes by tissue inhibitor of metalloproteinases.
Human recombinant tissue inhibitor of metalloproteinases (rTIMP) at 0.2-4.6 microM was found to stimulate the growth of normal human keratinocytes, in primary cultures on a plastic support, and toExpand
Involvement of Fibronectin Type II Repeats in the Efficient Inhibition of Gelatinases A and B by Long-chain Unsaturated Fatty Acids*
It is shown that long-chain fatty acids inhibit gelatinase A as well as gelatinase B with K i values in the micromolar range but had only weak inhibitory effect on collagenase-1 (MMP-1), as assessed using synthetic or natural substrates. Expand
UVA radiation stimulates ceramide production: relationship to oxidative stress and potential role in ERK, JNK, and p38 activation.
The results provide a possible mechanism for UVA-induced activation of stress kinases via ceramide formation, and show that, downstream of CER, UVA activated the Ser/Thr kinases ERK, JNK, and p38. Expand
An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion.
This introduction presents the best characterized matrikines, derived from elastin, connective tissue glycoproteins, or collagens, which suggest that they can play a significant role in the control of tumor progression. Expand
Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP
Batimastat, an inhibitor of furin convertase and timP-2, but not TIMP-1, totally abolished the influence of elastin-derived peptides (EDPs) on cell migration and tubulogenesis, thus favoring the involvement of MT1-MMP in such processes. Expand
Collagen zymography as a sensitive and specific technique for the determination of subpicogram levels of interstitial collagenase.
The use of casting native collagen type I in SDS-polyacrylamide gel (collagen zymography) for the determination of interstitial collagenase was used to demonstrate the increased expression of collagenase following treatment of human gingival fibroblasts with interleukin-1 beta. Expand
Proteolytic activity is involved in changes in intrafollicular insulin-like growth factor-binding protein levels during growth and atresia of ovine ovarian follicles.
Results suggest that changes in intrafollicular IGFBP proteolytic activity could be at least partly responsible for the changes in internal IGFBP levels that occur during follicular growth and atresia in the sheep and metalloprotease in healthy and atretic follicles as well as serine protease(s) in atretIC follicles are involved in IGFBP degradation. Expand