pemetrexed

Known as: L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-, Pemetrexed [Chemical/Ingredient], L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl) 
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Lung cancer is the foremost cause of cancer-related deaths world-wide. Both, the major forms of lung cancer, Non-small cell lung… (More)
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Highly Cited
2017
Highly Cited
2017
BACKGROUND Osimertinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that is selective for both… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE In the phase III PARAMOUNT trial, pemetrexed continuation maintenance therapy reduced the risk of disease progression… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Patients with advanced non-squamous non-small-cell lung cancer (NSCLC) benefit from pemetrexed maintenance therapy… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non-small-cell lung cancer (NSCLC… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non-small-cell lung cancer… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Patients with malignant pleural mesothelioma, a rapidly progressing malignancy with a median survival time of 6 to 9… (More)
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Highly Cited
1988
Highly Cited
1988
We have previously described the application of an automated microculture tetrazolium assay (MTA) involving dimethyl sulfoxide… (More)
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