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pemetrexed

Known as: L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-, Pemetrexed [Chemical/Ingredient], L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl) 
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (3)

AlimtaLY 231514pemetrexed disodium heptahydrate

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsFolic Acid AntagonistsNucleic Acid Synthesis Inhibitors
Folic AcidIn BloodNCIt Antineoplastic Agent Terminologyagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Tooth discoloration after the use of new pozzolan cement (Endocem) and mineral trioxide aggregate and the effects of internal bleaching.
Highly Cited
2008
Highly Cited
2008
Immunohistochemical analysis of nestin, osteopontin and proliferating cells in the reparative process of exposed dental pulp capped with mineral trioxide aggregate
術後1日で覆髄部直下に変性層が観察され(図 1a), その下層に軽度の炎症性細胞浸潤がみられた。5日後で は覆髄部直下に線維性基質形成が観察され(図 1b),7 日後には薄い被蓋硬組織が形成された。14… 
Highly Cited
2008
Highly Cited
2008
CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease
Highly Cited
2006
Highly Cited
2006
Human alveolar bone cells interact with ProRoot and tooth-colored MTA.
Highly Cited
2006
Highly Cited
2006
Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control
Binding of Src family kinases to membrane-associated polyoma virus middle T-antigen (PyMT) can result in the phosphorylation of… 
Highly Cited
2003
Highly Cited
2003
Investigation of the marginal adaptation of root-end filling materials in root-end cavities prepared with ultrasonic tips.
AIM To compare the surface topography of root apices following ultrasonic root-end preparation, and again after root-end fillings… 
Review
2002
Review
2002
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine.
Highly Cited
2002
Highly Cited
2002
Sealing ability of mineral trioxide aggregate and super-EBA when used as furcation repair materials: a longitudinal study.
Immediate sealing of furcation perforations enhances the repair process. The purpose of this study was to longitudinally compare… 
Highly Cited
2001
Highly Cited
2001
5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.
Highly Cited
1984
Highly Cited
1984
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
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