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pemetrexed

Known as: L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-, Pemetrexed [Chemical/Ingredient], L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl) 
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
BACKGROUND There is no recommended therapy for malignant pleural mesothelioma that has progressed after first-line pemetrexed and… Expand
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Highly Cited
2017
Highly Cited
2017
BACKGROUND Osimertinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) that is selective for both… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate… Expand
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Highly Cited
2009
Highly Cited
2009
OBJECTIVES To determine any long-term effects, 6 and 8 years after childhood enrollment, of the randomly assigned 14-month… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non-small-cell lung cancer (NSCLC… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non-small-cell lung cancer… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE Patients with malignant pleural mesothelioma, a rapidly progressing malignancy with a median survival time of 6 to 9… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Previous studies have demonstrated the short-term efficacy of pharmacotherapy and behavior therapy for attention… Expand
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Highly Cited
1995
Highly Cited
1995
This study determined the chemical composition, pH, and radiopacity of mineral trioxide aggregate (MTA), and also compared the… Expand
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Highly Cited
1988
Highly Cited
1988
We have previously described the application of an automated microculture tetrazolium assay (MTA) involving dimethyl sulfoxide… Expand
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