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pemetrexed

Known as: L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-, Pemetrexed [Chemical/Ingredient], L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl) 
A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (3)

AlimtaLY 231514pemetrexed disodium heptahydrate

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsFolic Acid AntagonistsNucleic Acid Synthesis Inhibitors
Folic AcidIn BloodNCIt Antineoplastic Agent Terminologyagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells…
The mechanism of action of an antifolate may be investigated using a variety of experimental methods. These include experiments… 
1997
1997
Figure 4. Typical Evolution of a Population of Networks Generated by (a) Mta Algorithm, (b) Cca Algorithm and (c) Ccas Algorithm. (a) (b) 6. Acknowledgments 7. References
[4] F. Dellaert, and J. Vandewalle, " Automatic design of cellular neural networks by means of genetic algorithms: finding a… 
Highly Cited
1994
Highly Cited
1994
A Vector Corrected High Power On-Wafer Measurement System with a Frequency Range for the Higher Harmomcs up to 40 GHz
A high power on-wafer measurement system based on the new microwave transition analyzer (MTA) HP 71500A has been developed for… 
1986
1986
Genetic variants of histocompatibility antigens from wild mice.
Had it not been for wild mice, the genetic analysis of Mta, a maternally transmitted histocompatibility antigen of mice, would… 
1985
1985
The metabolism of 5'-methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae.
Cordycepin sensitive mutants of Saccharomyces cerevisiae, which are permeable to 5'-deoxy-5'-methylthioadenosine (MTA), were used… 
1985
1985
Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids.
Maternally transmitted antigen (Mta) is a murine cell surface class I-like antigen that is defined by specific cytotoxic… 
1982
1982
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the… 
1982
1982
Mta, a maternally inherited cell surface antigen of the mouse, is transmitted in the egg.
Mta is a maternally transmitted cell surface antigen found in most mouse strains. It serves as a target for unrestricted T killer… 
1979
1979
A microtiter agglutination test for anti-Pasteurella multocida antibodies in turkeys.
A microtiter agglutination test (MTA) was developed for assaying anti-Pasteurella multocida antibodies in turkeys vaccinated with… 
1955
1955
Chemical and enzymatic changes associated with mouse liver necrosis in vitro.
Chemical and enzymatic changes have been studied in mouse liver undergoing necrosis or autolysis in vitro by incubating pieces of…