LY 231514

Known as: LY231514, LY-231514, 231514, LY 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1961-2017
0102019612017

Papers overview

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Highly Cited
2002
Highly Cited
2002
The purpose of this study was to identify predictive factors for severe toxicity caused by antifolate-chemotherapy using… (More)
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Highly Cited
1999
Highly Cited
1999
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for… (More)
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Highly Cited
1999
Highly Cited
1999
The proliferation rate of HT29 colon carcinoma cells was decreased by the multitargeted antifolate (MTA), LY231514. This effect… (More)
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1999
1999
PURPOSE To evaluate the efficacy and safety of the multitargeted antifolate LY231514 (MTA) in patients receiving initial… (More)
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1999
1999
The cytotoxicity of LY231514 was only partially alleviated by thymidine addition (5 microM) in GC3 human colon carcinoma cells… (More)
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1999
1999
PURPOSE Multitargeted antifolate (MTA; LY231514) has broad preclinical antitumor activity and inhibits a variety of intracellular… (More)
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Highly Cited
1998
Highly Cited
1998
Extensive biochemical and pharmacological evidence indicates that LY231514 is a novel antifolate antimetabolite. LY231514 is… (More)
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1997
1997
 Purpose: Cell cycle-related events in CCRF-CEM lymphocytic leukemia cells were examined subsequent to inhibition of thymidylate… (More)
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1995
1995
Four cell lines, the mouse L1210 leukaemia, the human W1L2 lymphoblastoid and two human ovarian (CH1 and 41M) cell lines, were… (More)
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1995
1995
PURPOSE To determine the toxicities, maximal-tolerated dose (MTD), pharmacokinetic profile, and potential antitumor activity of… (More)
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