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oxidosqualene

Known as: squslene oxide 
 
National Institutes of Health

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2 relations

Broader (1)

Squalene
analogs & derivatives

Papers overview

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Highly Cited
2004
Highly Cited
2004
Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.
The cultured cells and intact plants of Glycyrrhiza glabra (Fabaceae) produce betulinic acid and oleanane-type triterpene… Expand
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2004
2004
The monotopic membrane protein human oxidosqualene cyclase is active as monomer.
The monotopic integral membrane protein 2,3-oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol the first sterol… Expand
Highly Cited
2003
Highly Cited
2003
Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants.
Betula platyphylla var. japonica is a rich source of triterpenoid as it contains dammarane type triterpenes in the leaves, and… Expand
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2002
2002
Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis.
A random mutagenesis/in vivo selection approach was applied to generate and identify mutations that alter the product specificity… Expand
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Highly Cited
2002
Highly Cited
2002
Yeast Oxidosqualene Cyclase (Erg7p) Is a Major Component of Lipid Particles*
Oxidosqualene cyclase of the yeast encoded by the ERG7 gene converts oxidosqualene to lanosterol, the first cyclic component of… Expand
Highly Cited
2001
Highly Cited
2001
A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots
Many plants synthesize antimicrobial secondary metabolites as part of their normal program of growth and development, often… Expand
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Highly Cited
2001
Highly Cited
2001
Potent Anti-Trypanosoma cruzi Activities of Oxidosqualene Cyclase Inhibitors
ABSTRACT Trypanosoma cruzi is the protozoan agent that causes Chagas' disease, a major health problem in Latin America. Better… Expand
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Highly Cited
2000
Highly Cited
2000
Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol.
The Arabidopsis thaliana LUP1 gene encodes an enzyme that converts oxidosqualene to pentacyclic triterpenes. Lupeol and beta… Expand
Highly Cited
1999
Highly Cited
1999
Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases.
Two new triterpene synthase cDNAs, named as OEW and TRW, were cloned from olive leaves (Olea europaea) and from dandelion roots… Expand
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Highly Cited
1998
Highly Cited
1998
Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants.
Beta-amyrin, a typical pentacyclic triterpene having an oleanane skeleton, is one of the most commonly occuring triterpenes in… Expand
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